Zymox Plus Advanced Formula 1% Hydrocortisone Otic Dog & Cat Ear Infection Solution, 1.25-fl oz bottle

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About This Item

Details

  • Naturally occurring enzymes are highly effective against bacterial, fungal and yeast ear infections, plus the anti-inflammatory power of hydrocortisone. While this formula isn’t designed to treat dog and cat ear mites, it could help relieve symptoms and protect against secondary infections from yeast, bacteria, and fungus.
  • Proven antimicrobial LP3 Enzyme System inhibits, splits and destroys the offending organisms while leaving healthy cells alone.
  • Four additional biofilm-reducing enzymes destroy the hard-to-penetrate biofilm slime layer that obscures the microbe.
  • Ideal for cases of repeated infections or infections that won’t resolve, and bacteria will never develop a resistance to the enzymes. Great alternative to antibiotics and the non-toxic solution won’t irritate a pet’s sensitive or irritated skin and is great for dogs and cats.
  • Made in the USA.

Ingredients

Instructions

Learn More About Zymox From Our Team of Experts

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Questions & Answers

34 Customer Questions

Do you need a prescription for this or is it available without?

Can I give this to my dog while he takes amoxicillin?

Answer by DrMoore • Dec 16, 2025
Yes. It is safe.

What does “apply liberally” mean exactly ? I.e., how many drops of the solution should I use daily for a large dog ( standard poodle)?

Answer by Chewy • Mar 26, 2020
It is directed to apply a generously amount of solution to un-cleaned ear, filling ear canal.

Is it safe if ingested Some cats lick their paws and pass it by the ear area ear after using these drops

Answer by Chewy • Oct 30, 2019
This solution is safe if accidentally ingested.
Reviews
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4.8
Rated 4.8 out of 5 stars
2432 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Durability

86% Positive

Ease of Use

93% Positive

Effectiveness

93% Positive

Safety

89% Positive

1212 Customer Reviews

Rated 5 out of 5 stars
By Sabrina on Mar 26, 2026

If I could give 10 stars I would!

I have had my boy almost 7 months now, since the day I got him he's been battling ear issues, that gave him antibiotic ear drops that just seem to worsen it and

I have had my boy almost 7 months now, since the day I got him he's been battling ear issues, that gave him antibiotic ear drops that just seem to worsen it and make his ears hurt, he's been on oral antibiotics at least three times nothing worked, until this! After reading about what this product is for I could clearly see that the infection and the good that was coming out of his ear is exactly what this stuff is for it's a shame the vet didn't even know that because it's antibiotic resistant and you need this kind of medication to cure it my boy has only been on it now for 4 days and is way better than he's been in the last 6 months I was apprehensive about spending the money on it but it was well worth it.. to anybody out there that's had the same issue with any other pets constant ear infections this is probably exactly what they need, because the infection is antibiotic resistant, so thankful I got this

Rated 5 out of 5 stars
By TANA on Feb 27, 2026

It Worked !

Bailey had 3 ear infections in one month. I used what the Vet gave me but it came back a week later. Used the Vet given drops again and it came back again ! It was

Bailey had 3 ear infections in one month. I used what the Vet gave me but it came back a week later. Used the Vet given drops again and it came back again ! It was diagnosed as a yeast infection the first time around. Well I ordered Zymox Plus and when it arrived I started to treat his ear according to the instructions and the redness left quickly and the constant head shaking of his ears stopped ! Finally ! Apparently his particular yeast infection lost the battle with the Zymox Plus !

Rated 1 out of 5 stars
By Courtney on Jan 24, 2026

Everything they claim is false

I bought this because their description of this medication stated that the ear drops help getting rid of any bacterial or fungal infections. My cat had a really

I bought this because their description of this medication stated that the ear drops help getting rid of any bacterial or fungal infections. My cat had a really bad ear and I was in search of medicine to ais getting rid of it. I was desperate bc my vet would not see my cat without payment. All this description of this medicine led me to believe that it will get rid of a ear infection. Let's just say the ingredients are no different than the 15 dollar ear care cleaning swabs. The difference I was lead to believe with this product would kill bacterial and fungal infections. It does not. It only lessens the irritation part of ear infection. Don't trust their description. And I also thought I was getting the sale price, only to get my bank statement and it was the full amount. Never would I pay 40 bucks for mainly hydrocortisone. I'm definitely going to be asking for my money back!!

Rated 5 out of 5 stars
By Susan on Mar 11, 2026

Excellent Treatment for Ear Troubles

My 14 year old Lab has chronic ear problems. She is resistant to cleaning or treating. This product is wonderful because I need only put a drop or two into her ears

My 14 year old Lab has chronic ear problems. She is resistant to cleaning or treating. This product is wonderful because I need only put a drop or two into her ears and it calms the itching and dissolves the exudate without cleaning. No struggle, no anxiety. Just relief.

Rated 5 out of 5 stars
By Rebecca on Mar 26, 2026

Pricey but effective

I was a little iffy on the price but needed something for my dog’s ears, and I was willing to do anything. I bought this and within twodays her ears looked so much

I was a little iffy on the price but needed something for my dog’s ears, and I was willing to do anything. I bought this and within twodays her ears looked so much better and feeling better too. She’s a happy dog now.

Rated 5 out of 5 stars
By Madeline on Jan 13, 2026

Fixed ear infection within 24 hours.

This is amazing. Like actually incredible. I got home from a trip and my golden had the worst ear infection ive ever seen. Shaking her head, black wax EVERYWHERE

This is amazing. Like actually incredible. I got home from a trip and my golden had the worst ear infection ive ever seen. Shaking her head, black wax EVERYWHERE. I mean everywhere, there was a shred of skin uncovered in her ear. Absolutely besides herself crying when you pet her ear even lightly. Of course I was livid at our sitter. This was a saturday night, vets closed til monday. I bought this in the meantime along with regular ear cleaner, it got here monday morning, vet was scheduled for tuesday. Come tuesday they were so impressed. She doesnt even need extra medication from them. Absolutely grateful. The price is super high but its worth it.

Rated 1 out of 5 stars
By Rick on Feb 22, 2026

Product did knock out infection within a couple days

Ufortuneltly my standard poodle had seizures three times after use. Although we have still not been able to keep him infextion free, he has not had any more seizures

Ufortuneltly my standard poodle had seizures three times after use. Although we have still not been able to keep him infextion free, he has not had any more seizures since we stopped using this medication. Interested to know if there are any others have had the same expeirence

Rated 5 out of 5 stars
By Rebecca on Mar 24, 2026

Helps with reoccurring ear infections

I’ve been using this item for the past year. Our young lab has had multiple ear infections. We use it once a week and it has helped tremendously keeping his ear

I’ve been using this item for the past year. Our young lab has had multiple ear infections. We use it once a week and it has helped tremendously keeping his ear infections at bay.

Rated 3 out of 5 stars
By Candi on Feb 2, 2026

Not what I had expected, but worked in combination with something else.

I was not expecting this product to be a gel. I used it in combination with another product to get rid of what I suspect, was yeast inside of her ear. I used the

I was not expecting this product to be a gel. I used it in combination with another product to get rid of what I suspect, was yeast inside of her ear. I used the other eardrops to clean it out. And this as a follow up. Just stop her from itching. I did expect it to a liquid, but it is a gel. I bit difficult to apply, but so far it has worked.

Rated 4 out of 5 stars
By Mary on Jan 28, 2026

Effective

I had been trying to keep my dog's ear clean for about a month, but the dark brown ear wax kept returning. She also kept scratching at it. I decided to try this

I had been trying to keep my dog's ear clean for about a month, but the dark brown ear wax kept returning. She also kept scratching at it. I decided to try this Zymox solution and followed the directions to a 't,' and it worked wonderfully-the brown ear wax is gone and she doesn't scratch. We live in the boondocks, so this saved me a trip to the vet and a vet bill.