Zycosan Injection for Horses, 250-mg/mL, 7.5 mL, 1 vial

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($15.40 /mL)
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About This Item

Details

  • The only FDA approved pentosan polysulfate sodium injection for horses
  • Indicated for the control of clinical signs associated with osteoarthritis in horses
  • Zycosan’s active ingredient is derived from the Beechwood tree which facilitates sustainability and consistency of supply
  • Not limited to use for specific joints
  • Convenient; 4 intramuscular injections required

Ingredients

Instructions

FAQ

4.5
Rated 4.5 out of 5 stars
26 Ratings

10 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 4 out of 5 stars
By Danielle on Jun 26, 2025
Kalahari Sun
Kalahari Sun

Excellent everything .. just seeking value-add, if possible

Appreciate having access to needed meds, the direct connection with the Vet's office to fill the Rx, and bringing the product to my door quickly!! Only challenge

Appreciate having access to needed meds, the direct connection with the Vet's office to fill the Rx, and bringing the product to my door quickly!! Only challenge I had was understanding the dosing. This is feedback for the manufacturer more than Chewy, but perhaps Chewy can help, as I did have a call with Chewy Customer Service and did not receive the right info. Challenge: the med vial is 7.5ml. The instructions are for 3mg/kg (1.4mg/lb). Soo .. user has to convert mg to ml and kg to pounds to figure it out! ChatGPT calculated 8.81 ml for my 970lb horse. Chewy Pharmacist told me something else (can't remember, but not the same number as above or below). My Vet told me 5.3 ml. Very confusing. Would be helpful to have some kind of weight dosing matrix/chart. Thank you, though. I love Chewy!

By Danielle on Jun 26, 2025
Kalahari Sun
Kalahari Sun

Rated 4 out of 5 stars
By elizabeth on Jun 22, 2024

Zycosan injection results

My horse has arthritis in Right pastern bone and developed a limp, drags the hoof and trips often. His veterinarian prescribed Zycosan 5ml injection per week for

My horse has arthritis in Right pastern bone and developed a limp, drags the hoof and trips often. His veterinarian prescribed Zycosan 5ml injection per week for four weeks. Immediate results (after four weeks) were positive , he continues to limp, but less noticeably, and is no dragging hoof or tripping.

By elizabeth on Jun 22, 2024

Rated 1 out of 5 stars
By Jennifer on Jun 26, 2025

Never again,...

Our vet office gave a lecture. They handed out $40 coupons for Zycosan. I ordered thru Chewy. The rebate company rejected our claim without a reason.

Our vet office gave a lecture. They handed out $40 coupons for Zycosan. I ordered thru Chewy. The rebate company rejected our claim without a reason. When I inquired, they said it had to be purchased through a vet. Never again,...very unprofessional on the part of Zycoan.

By Jennifer on Jun 26, 2025

Rated 5 out of 5 stars
By Alyssa on Jan 20, 2026
Mercedes
Mercedes

Significant improvements in my mare

My vet recommended a course of zycosan for my mare who was struggling with hind end lameness. After just one course of this she made significant improvements and

My vet recommended a course of zycosan for my mare who was struggling with hind end lameness. After just one course of this she made significant improvements and is able to be started back into work. Over the past year we tried multiple different treatments and this one has made the most progress so far. Absolutely amazed with it and would definitely recommend giving it a shot if your vet recommends it!

By Alyssa on Jan 20, 2026
Mercedes
Mercedes

Rated 3 out of 5 stars
By Ann on May 12, 2026

The price, ugh!

I remember when I could buy 10 doses of pentosan for about half what this tested version costs. It's a great product for horses with arthritis, but no longer competitive

I remember when I could buy 10 doses of pentosan for about half what this tested version costs. It's a great product for horses with arthritis, but no longer competitive on price. No wonder people are getting out of horses!

By Ann on May 12, 2026

Rated 5 out of 5 stars
By Barbara on Apr 18, 2026

Quite helpful for my horses’ arthritis

He moves fluidly and without pain.

He moves fluidly and without pain.

By Barbara on Apr 18, 2026

Rated 5 out of 5 stars
By Shannon on Dec 22, 2025
Lucy
Lucy

Cost

1st time I’m trying this product.

1st time I’m trying this product.

By Shannon on Dec 22, 2025
Lucy
Lucy

Rated 5 out of 5 stars
By Ben on Mar 5, 2026

Accuracy in your shipping

Hoping it’s helping

Hoping it’s helping

By Ben on Mar 5, 2026

Rated 4 out of 5 stars
By Tobie on Oct 10, 2024

It’s quite a bit of product to inject. But the price point is great

Not really sure if it’s working yet, we have only done a couple injections so far.

Not really sure if it’s working yet, we have only done a couple injections so far.

By Tobie on Oct 10, 2024

Rated 5 out of 5 stars
By Nicole on Oct 9, 2024

Good product

Great anti inflammatory for joints

Great anti inflammatory for joints

By Nicole on Oct 9, 2024