Zenrelia (ilunocitinib tablets) for Dogs, 6.4-mg, 30 tablets

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About This Item

Details

  • Zenrelia relieves itching in dogs due to allergic dermatitis and controls atopic dermatitis.
  • Ilunocitinib, the active ingredient in Zenrelia, works by reducing the itch and inflammatory response in your dog's skin due to allergies.
  • The most common side effects reported with this dog dermatitis treatment were vomiting, diarrhea and tiredness; please see product insert for more information.
  • The once-daily tablet can be given with or without food from the comfort of your home.

Ingredients

Instructions

FAQ

Zenrelia (ilunocitinib tablets)

Zenrelia is a prescription medication that relieves itching in dogs due to allergic dermatitis and helps control atopic dermatitis. The active ingredient, ilunocitinib, reduces the inflammatory response in your dog's skin caused by allergies, making your dog feel less itchy.

Once-daily Tablet

Zenrelia comes in an oral tablet that’s given once a day with or without food. It's easy to fit into your dog's daily routine. Always follow your veterinarian’s instructions. 

Prescription Only

Zenrelia is a prescription itch relief medication for dogs at least 12 months of age. Ask your veterinarian if Zenrelia can help get your dog back to normal itching levels. They will evaluate your dog’s symptoms and determine the right tablet.

Dogs should not take Zenrelia for a time period before and after vaccination. Discuss your dog’s vaccine schedule with your veterinarian.

Signs of Allergic Dermatitis in Dogs

The most common sign of allergic dermatitis is excessive itching. Your dog might also bite or lick the itchy skin. Although symptoms might start as mild, they can progress to conditions such as hair loss and skin infection.

About Elanco

Elanco is a global leader in animal health dedicated to innovating and delivering products and services to prevent and treat disease in farm animals and pets, creating value for farmers, pet owners, veterinarians, stakeholders, and society as a whole.

INDICATIONS

Zenrelia is a prescription medication used to control itching and inflammation associated with skin allergies for dogs over 12 months of age.

IMPORTANT SAFETY INFORMATION

See package insert including the Boxed Warning. For full prescribing information speak with your veterinarian, call 1 888 545 5973 or visit www.elancolabels.com/us/zenrelia.

WARNING: VACCINE-INDUCED DISEASE AND INADEQUATE IMMUNE RESPONSE TO VACCINES. Based on results of the vaccine response study, dogs receiving Zenrelia are at risk of fatal vaccine-induced disease from modified live virus vaccines and inadequate immune response to any vaccine. Discontinue Zenrelia for at least 28 days to 3 months prior to vaccination and withhold Zenrelia for at least 28 days after vaccination. Dogs should be up to date on vaccinations prior to starting Zenrelia. Do not use in dogs less than 12 months old or dogs with a serious infection. Dogs should be monitored for the development of infections because Zenrelia may increase the chances of developing an infection. Neoplastic conditions (benign and malignant) were observed during clinical studies. The most common side effects were vomiting, diarrhea and tiredness. Zenrelia has not been tested in dogs used for breeding, pregnant, or lactating dogs and has not been evaluated in combination with glucocorticoids, cyclosporine, or other immune suppressive drugs.

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4.7
Rated 4.7 out of 5 stars
1603 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

86% Positive

Ingredients

84% Positive

Long-Term Benefits

85% Positive

648 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 1 out of 5 stars
By Michael on Mar 30, 2026

drugs that don't work

LAME ! ALL the drugs that all these vets recommend SUCK ! don't settle for APOQUEL or ZENERELLA ! THE ONLY thing that has worked on my Beagle is called CYCLOSPORINE

LAME ! ALL the drugs that all these vets recommend SUCK ! don't settle for APOQUEL or ZENERELLA ! THE ONLY thing that has worked on my Beagle is called CYCLOSPORINE Modified - she has totally stopped shedding and scratching ALTOGETHER ..... it's like the miracle drug that No VET will tell you about for some reason ! maybe because it's about 1/2 the cost of the other 2 "treatments" (keep the PROBLEM but lessen symptoms)

Rated 5 out of 5 stars
By Wendy on Mar 22, 2026

Something that finally works!!!

My poor little Yorkie has been plagued by extreme itching for about 4 years now. Apoquel only worked for about 8 hours but isn't recommended to take more than once

My poor little Yorkie has been plagued by extreme itching for about 4 years now. Apoquel only worked for about 8 hours but isn't recommended to take more than once a day, meaning 16 hours of misery. I've tried both prescription & natural remedies but nothing helped. Zenrelia literally worked IMMEDIATELY and only needed once a day. No more itching!

Rated 5 out of 5 stars
By Haley on Feb 27, 2026

This saved my dogs life (and my sanity)

My pug, Luna, started suffering from horrible allergies. It started about 5 years ago as just itchy skin and quickly developed into scaly scabs, missing fur, and

My pug, Luna, started suffering from horrible allergies. It started about 5 years ago as just itchy skin and quickly developed into scaly scabs, missing fur, and her actually cutting her face open from itching so much. We tried everything under the sun. Every pill, every shot, every food diet, yet nothing worked. I would be up all hours of the night with her crying just feeling like the worst owner ever because I couldn't figure it out. I switched to a vet who specializes in dermatology and he recommended this. After two days, I noticed an immediate difference. After 3 months, I finally had my dog back! She's back to her playful and goofy self! Highly recommend!!

Rated 5 out of 5 stars
By Shannon on Mar 15, 2026

A new dog

Wow is all I can say this time last year my white pitbull looked like a naked mole rat his allergies were so bad he was bald from all the scratching now he's calm

Wow is all I can say this time last year my white pitbull looked like a naked mole rat his allergies were so bad he was bald from all the scratching now he's calm scratches very little and has a beautiful white coat again... Best medication on the market trust me we have tried all that out there this is the only medicine that works thank you zenrelia

Rated 5 out of 5 stars
By Tessa on Feb 2, 2026

Stopped Itch Immediately!

My dog had struggled with itching for more than a year every day. He had sores and bruised skin. I had to put him in a cone because he would not stop. I tried Benadryl

My dog had struggled with itching for more than a year every day. He had sores and bruised skin. I had to put him in a cone because he would not stop. I tried Benadryl and Claritin which didn't work. I put him on Apoquel which sort of helped but was outrageously expensive. My vet then recommended Zenrelia and I was desperate so I tried it. It completely took the itch away and was even more effective than Apoquel and cheaper. It definitely isn't cheap overall but the results make it worth it. My GSD is completely comfortable, can rest, and his skin has cleared up. The only downside is you have to be sure that they are not going to do any vaccines soon. I worked with my vet on that and he was fine though. So happy I found this!

Rated 1 out of 5 stars
By Brent on Mar 31, 2026

Lost delivery

I've ordered my dog's medication twice from Chewy in 3 months. Both deliveries have been lost/misplaced. It's not a toy. It's a freaking prescription. Chewy needs

I've ordered my dog's medication twice from Chewy in 3 months. Both deliveries have been lost/misplaced. It's not a toy. It's a freaking prescription. Chewy needs to contact me immediately for the information on this order, and fix this.

Rated 5 out of 5 stars
By PAUL on Mar 19, 2026

New prescription for Zenralia

Prompt contact with the vet for the prescription, then very speedy shipping. thank you. It is also a little less expensive than the apoquel that we have been using

Prompt contact with the vet for the prescription, then very speedy shipping. thank you. It is also a little less expensive than the apoquel that we have been using. Vet said it is actually a different type of antihistamine, and may work better to help relieve itching.

Rated 5 out of 5 stars
By Heather on Jan 30, 2026

Nice rep :) This new medication works!

Y'all have the nicest phone reps :) This new Rx for itching has made a huge difference for Blue - paw licking & tummy so red - just awful. Benedryl helped for a

Y'all have the nicest phone reps :) This new Rx for itching has made a huge difference for Blue - paw licking & tummy so red - just awful. Benedryl helped for a while but doping my dog multiple times a day was not ok. Vet suggested still giving it 2x a day (2 each dose) but I am not doing that - the Zenrelia is working for my 100 lb baby & doesn't knock him out all day. The Rx I was given said to give 2x a day but 1x has been working for Blue. Hopefully, for other dogs too - it's $$$ if given 2x daily.

Rated 5 out of 5 stars
By Lee on Mar 19, 2026

Amazing!!!

My dog has suffered from allergies for about 18 months. She was so miserable and we tried everything. One hour after taking her first dose and she is itch free

My dog has suffered from allergies for about 18 months. She was so miserable and we tried everything. One hour after taking her first dose and she is itch free. This is amazing and she is back to her silly self again.

Rated 4 out of 5 stars
By Troy on Jan 28, 2026

Identical to apoquel

My dog is a white american bully that seems to be allergic to the air even, he was on apoquel for atleast 5 years, it worked wonders until he started becoming immune

My dog is a white american bully that seems to be allergic to the air even, he was on apoquel for atleast 5 years, it worked wonders until he started becoming immune to it, im not going monthly and spending 100 plus on a shot so he tried this. It works like apoquel once did but it does where off fast if a dose is missed and every allergy medicine needs your dogs liver monitored so you need to decide which is a worse problem. My boys allergies were so bad we thought he was gonna ripped himself apart. So medicine it is. Hes now almost 10 and has not had an adverse lasting problems.