Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box), 6 Chewable Tablets (6-mos. supply)

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About This Item

Details

  • Triple Protection in One Monthly Chew: Simparica Trio provides complete flea and tick prevention for dogs plus protection against heartworms and intestinal worms. For puppies eight weeks and older weighing at least 2.8 lbs.
  • Heartworm Protection: Proven 100% effective against heartworm disease in studies supporting FDA approval.
  • Kills 6 Types of Ticks & Helps Prevent Lyme Infections: The only combination preventative proven to kill Gulf Coast, Deer, American Dog, Lone Star, Brown Dog, and Asian Longhorn ticks.
  • Stops Fleas & Treats Intestinal Worms: Kills fleas before they lay eggs to prevent infestations. Also treats and controls roundworms and hookworms.
  • Easy Once-a-Month Dosing: Give with or without food. Backed by a 100% satisfaction guarantee on prevention.

Ingredients

Instructions

FAQ

Learn More About Simparica Trio From Our Team of Experts
4.8
Rated 4.8 out of 5 stars
4210 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

91% Positive

Effectiveness

90% Positive

Ingredients

89% Positive

Long-Term Benefits

89% Positive

1214 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Misty on Mar 24, 2026

Great protection against Ticks, Fleas and the outcome

My labs take this Pill like a treat. They don’t mind the taste. It’s monthly and they know when I get there own little bag out it’s time to take it. They have

My labs take this Pill like a treat. They don’t mind the taste. It’s monthly and they know when I get there own little bag out it’s time to take it. They have been in this a year and no sides effects or digestive issues. We have had no issues with fleas or ticks. Believe be they love the woods and to swim especially or Huckleberry.


Rated 2 out of 5 stars
By Rita on Mar 31, 2026

Made my dog sick

After giving the medicine to my dog, she became lethargic. A few days later she had diarrhea. I stopped using medicine and will try to find a medicine that doesn’t

After giving the medicine to my dog, she became lethargic. A few days later she had diarrhea. I stopped using medicine and will try to find a medicine that doesn’t treat so many things at one time. Seemed like a convenient pill to treat worms, fleas, and ticks but it did not agree with my dog.


Rated 5 out of 5 stars
By Bonita on Mar 29, 2026

No fleas or tics & heartworm negative

I have great pyrenees & use Simparica Trio monthly. My dogs have not experienced any side effects & I have not seen any fleas or tics on them. They have tested

I have great pyrenees & use Simparica Trio monthly. My dogs have not experienced any side effects & I have not seen any fleas or tics on them. They have tested negative for heartworm. Best to go with a brand your vet recommends for the breed of dog that you have.


Rated 5 out of 5 stars
By Eileen on Feb 27, 2026

Simparica

We like using this medication for our dogs. I order a lot of products from chewy but this was the first medication. The only thing I didn’tlike was having to drive

We like using this medication for our dogs. I order a lot of products from chewy but this was the first medication. The only thing I didn’tlike was having to drive to my vet 40 miles away to get a handwritten prescription to mail in. Other places would call in the prescriptionorder, but other than that I like chili. Next time I’ll just coordinate a prescription with a vet visit.


Rated 4 out of 5 stars
By christina on Apr 3, 2026

Discounted meds

I have been giving Simparica Trio to my dog for five years and have had no issues. It was fast shipping and works as described for fleas and ticks. Only negative

I have been giving Simparica Trio to my dog for five years and have had no issues. It was fast shipping and works as described for fleas and ticks. Only negative is the price is always higher after the first time you order it


Rated 2 out of 5 stars
By Jamie on Feb 2, 2026
Top 1000 Contributor

Took 3 months to work

Took 3 months to fully work we did revolution on cats and this on dogs. Was pain to get then to eat it 1 out of 6 just took it rest had to fight with which 100

Took 3 months to fully work we did revolution on cats and this on dogs. Was pain to get then to eat it 1 out of 6 just took it rest had to fight with which 100 plus dogs dont eat much they dont want to. Very expensive for how well it works. We also use it with knock out for house and carpets. We use cap star as well to help as dose wears off before next dose. The fleas are horrible nowadays and not much works so better then some but not great


Rated 5 out of 5 stars
By Linda on Mar 21, 2026

The amount of prevention.

It is a bit pricey but Gabe is a biiig boy. Worth it for the prevention. If buying heartworm and flea and tick, etc., seperately it would be probably be comparable

It is a bit pricey but Gabe is a biiig boy. Worth it for the prevention. If buying heartworm and flea and tick, etc., seperately it would be probably be comparable. Totally pleased with the product and price.


Rated 5 out of 5 stars
By Kimmie on Feb 23, 2026

Free replacement of miss delivered product

We thought that the delivery was misdelivered; and Chewy immediately replaced the missing delivery. Eventually the missing package was delivered and they did not

We thought that the delivery was misdelivered; and Chewy immediately replaced the missing delivery. Eventually the missing package was delivered and they did not require us to return the product nor did they charge me for new package. This type of customer service makes for great customer service.


Rated 4 out of 5 stars
By Tammy on Apr 3, 2026

No problem

This seems to work. His vet checkup was good. No parasites of any kind. They are not chewy so my dog doesn’t like it but he gets it anyway.

This seems to work. His vet checkup was good. No parasites of any kind. They are not chewy so my dog doesn’t like it but he gets it anyway.


Rated 5 out of 5 stars
By Paige on Jan 5, 2026

Tried and true!

This med was recommended to us by our vet, and has been really great for our dogs - as we live in a high tick area. It’s helped keep them off our dogs, they’re never

This med was recommended to us by our vet, and has been really great for our dogs - as we live in a high tick area. It’s helped keep them off our dogs, they’re never bit by ticks anymore, and it’s easy for them to take. It comes as a “treat” and our dogs have no problem taking this med. Thankful for that! The price is a bit high, but you really get what you pay for, as this med is given for multiple reasons (flea, tick, etc). We are very happy with this!