Simparica Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 3 Chewable Tablets (3-mos. supply)

Have a Chewy account?
Sign in to quickly add pet health details.
$39.62 First Time Autoship Price
this order
Save 50% (up to $50) today when you set up Autoship. 

$75.28 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Never miss a dose with easy refills
  • Skip, change, or cancel anytime
$79.24 Chewy Price
($26.42 /ea)
Promo, Save 20% on first Rx order with code RX20

In Stock
FREE delivery
Usually arrives in 3-5 days
Prescription approval made easy
We’ll reach out to your vet clinic.
Medications ship separately. Delivery times may vary.

About This Item

Details

  • 35-Day Flea and Tick Prevention for Dogs: Simparica is a tasty, once-a-month chewable that protects your dog from fleas and ticks for 35 days, even if the next dose is a few days late.
  • Kills 6 Types of Ticks: Proven to kill Gulf Coast, Brown Dog, Deer, American Dog, Lone Star, and Asian Longhorned ticks.
  • Helps Prevent Lyme Infections: FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Fast-Acting Relief: Starts killing fleas within 3 hours and ticks within 8 hours. Kills adult fleas before they lay eggs to help stop infestations fast.
  • Tasty, Once-a-Month Chewable: Pork-liver flavored for easy dosing. Approved for dogs 6 months and older weighing at least 2.8 lbs, and backed by a 100% satisfaction guarantee on prevention.

Ingredients

Instructions

FAQ

Learn More About Simparica From Our Team of Experts

Protects Dogs From Ticks & Fleas for 35 days

Simparica is tasty pork liver-flavored, veterinarian-recommended monthly chew that protects your dog from fleas and ticks for a full 35 days.[1] It works fast and starts to kill fleas in 3 hours and ticks in 8 hours.[2] Simparica is approved for dogs 6+ months of age, weighing 2.8 lbs or more.

FDA-Approved to Prevent Lyme Infections*

Because it kills deer ticks, Simparica is FDA-approved to block infections that may cause Lyme disease. It kills 6 different types of ticks, including:

  • Gulf Coast Tick
  • Deer Tick
  • American Dog Tick
  • Lone Star Tick
  • Brown Dog Tick
  • Asian Longhorned Tick

Satisfaction Guaranteed

Simparica comes with a 100% satisfaction guarantee on prevention—so you can feel confident choosing fast, reliable protection. It’s a simple way to stay proactive about your dog’s care, with support you can count on.

Protect Your Dog & Earn Rewards From Zoetis

Your 6-or 12-count Simparica purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future vet care and more! Learn More at zoetispetcare.com/rewards

About Zoetis, the Makers of Rimadyl

At Zoetis, we’ve helped pets live their best lives for over 70 years. Zoetis offers a comprehensive range of products to support your pet’s health—from pest prevention and pain management to allergic itch relief and more. Know that we’ll always be here for you and your pet, no matter what.

Shop Zoetis

IMPORTANT SAFETY INFORMATION

Simparica is for use only in dogs 6 months of age and older. Simparica, which contains sarolaner, a member of the isoxazoline class, may cause neurologic signs such as tremors, unsteadiness, and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding, or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaPI.com.

*Data on file, Zoetis Services LLC.

References:Six RH, Liebenberg J, Honsberger NA, Mahabir SP. Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ctenocephalides felis on dogs. Parasit Vectors. 2016;9:90Honsberger NA, Six RH, Heinz TJ, et al. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67–72 (AR-04287).

SMP-00748

4.7
Rated 4.7 out of 5 stars
3052 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

90% Positive

Effectiveness

90% Positive

Ingredients

86% Positive

Long-Term Benefits

93% Positive

1016 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 3 out of 5 stars
By Amy on Mar 12, 2026

Works well for fleas didn’t prevent Lyme disease

This work really well for my husky for fleas but not preventing Lyme disease. My dog was diagnosed with Lyme disease at his yearly exam. I purposely looked for something

This work really well for my husky for fleas but not preventing Lyme disease. My dog was diagnosed with Lyme disease at his yearly exam. I purposely looked for something that protects against ticks because I live in the country. Now my boy has a month of antibiotics.


Rated 5 out of 5 stars
By Susie on Mar 24, 2026

Works great

Some oral flea pills upset my dogs stomach, he was lethargic & would sometimes vomit, but this formula causes no issues. My dogs had no fleas/ticks while on this

Some oral flea pills upset my dogs stomach, he was lethargic & would sometimes vomit, but this formula causes no issues. My dogs had no fleas/ticks while on this medication. Just wish it was over the counter & less expensive.


Rated 3 out of 5 stars
By David on Apr 1, 2026

Awesome product

Awesome product. Been using it for years but this was the first time ordering from chewy. It was delivered then the wind blew the box away. I watched it on camera

Awesome product. Been using it for years but this was the first time ordering from chewy. It was delivered then the wind blew the box away. I watched it on camera. Searched for two days with no luck.


Rated 2 out of 5 stars
By myriam on Feb 4, 2026

Worked for a while until it didnt

My dog has been on it for one year. I was ok until lately. Took my dog to the dog park she started scratching. Then it went away. Two months after I take the dog

My dog has been on it for one year. I was ok until lately. Took my dog to the dog park she started scratching. Then it went away. Two months after I take the dog to the beach. Full on scratches, I removed 12 tick or flea from her fur. They were big and full of blood. That thing doesn’t do the job. Unfortunately have to go back to pricier Bravecto that is actually always been working great.


Rated 5 out of 5 stars
By Samuel on Feb 24, 2026

Ease of ordering and price

I love how chewy’s makes ordering and their price beat my vet’s price by over $80 which made the choice very easy. The auto shipment arrives well in advance of the

I love how chewy’s makes ordering and their price beat my vet’s price by over $80 which made the choice very easy. The auto shipment arrives well in advance of the last dose so that no worries about running out


Rated 5 out of 5 stars
By Tommy on Apr 1, 2026

It works!

Have used Simpatica for 5 years and have never seen a flea and only dead ticks. Our dog is s house dog but is outside quite a bit.

Have used Simpatica for 5 years and have never seen a flea and only dead ticks. Our dog is s house dog but is outside quite a bit.


Rated 5 out of 5 stars
By Sandra on Feb 26, 2026

is to administer

When I rescued my fur baby it was determined she had the dreaded heartworm. After expensive treatments she was free of them. I feel the medication has prevented

When I rescued my fur baby it was determined she had the dreaded heartworm. After expensive treatments she was free of them. I feel the medication has prevented a re-infection


Rated 2 out of 5 stars
By Regina on Feb 1, 2026

Why has the cost increased so much?

Our dog has been on this for 8 years and used to cost $110 for a 6 month supply in 2022. We’ve never had any issues with this medication and chewy is wonderful,

Our dog has been on this for 8 years and used to cost $110 for a 6 month supply in 2022. We’ve never had any issues with this medication and chewy is wonderful, but the steep skyrocketing price has us questioning alternatives.


Rated 5 out of 5 stars
By Leo on Mar 10, 2026

always easy

getting my dog's prescription medicines through Chewy is always easy and effortless. they really do it all and keep you informed along the way

getting my dog's prescription medicines through Chewy is always easy and effortless. they really do it all and keep you informed along the way


Rated 5 out of 5 stars
By MICHELLE on Mar 2, 2026

works

def keeps them bugs off, just hate giving it to them being its poison going into their bodies but gotta keep the bugs away

def keeps them bugs off, just hate giving it to them being its poison going into their bodies but gotta keep the bugs away