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Simparica Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 3 Chewable Tablets (3-mos. supply)

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About This Item

Details

  • 35-Day Flea and Tick Prevention for Dogs: Simparica is a tasty, once-a-month chewable that protects your dog from fleas and ticks for 35 days, even if the next dose is a few days late.
  • Kills 6 Types of Ticks: Proven to kill Gulf Coast, Brown Dog, Deer, American Dog, Lone Star, and Asian Longhorned ticks.
  • Helps Prevent Lyme Infections: FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Fast-Acting Relief: Starts killing fleas within 3 hours and ticks within 8 hours. Kills adult fleas before they lay eggs to help stop infestations fast.
  • Tasty, Once-a-Month Chewable: Pork-liver flavored for easy dosing. Approved for dogs 6 months and older weighing at least 2.8 lbs, and backed by a 100% satisfaction guarantee on prevention.

Ingredients

Instructions

FAQ

Learn More About Simparica From Our Team of Experts

Protects Dogs From Ticks & Fleas for 35 days

Simparica is tasty pork liver-flavored, veterinarian-recommended monthly chew that protects your dog from fleas and ticks for a full 35 days.[1] It works fast and starts to kill fleas in 3 hours and ticks in 8 hours.[2] Simparica is approved for dogs 6+ months of age, weighing 2.8 lbs or more.

FDA-Approved to Prevent Lyme Infections*

Because it kills deer ticks, Simparica is FDA-approved to block infections that may cause Lyme disease. It kills 6 different types of ticks, including:

  • Gulf Coast Tick
  • Deer Tick
  • American Dog Tick
  • Lone Star Tick
  • Brown Dog Tick
  • Asian Longhorned Tick

Satisfaction Guaranteed

Simparica comes with a 100% satisfaction guarantee on prevention—so you can feel confident choosing fast, reliable protection. It’s a simple way to stay proactive about your dog’s care, with support you can count on.

Protect Your Dog & Earn Rewards From Zoetis

Your 6-or 12-count Simparica purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future vet care and more! Learn More at zoetispetcare.com/rewards

About Zoetis, the Makers of Rimadyl

At Zoetis, we’ve helped pets live their best lives for over 70 years. Zoetis offers a comprehensive range of products to support your pet’s health—from pest prevention and pain management to allergic itch relief and more. Know that we’ll always be here for you and your pet, no matter what.

Shop Zoetis

IMPORTANT SAFETY INFORMATION

Simparica is for use only in dogs 6 months of age and older. Simparica, which contains sarolaner, a member of the isoxazoline class, may cause neurologic signs such as tremors, unsteadiness, and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding, or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaPI.com.

*Data on file, Zoetis Services LLC.

References:Six RH, Liebenberg J, Honsberger NA, Mahabir SP. Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ctenocephalides felis on dogs. Parasit Vectors. 2016;9:90Honsberger NA, Six RH, Heinz TJ, et al. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67–72 (AR-04287).

SMP-00748

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Reviews
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4.7
Rated 4.7 out of 5 stars
3248 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

91% Positive

Effectiveness

90% Positive

Ingredients

86% Positive

Long-Term Benefits

93% Positive

1068 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 4 out of 5 stars
By RoxiJo on Jun 7, 2020

Simpirica Review

My Adult dog weighing in at 77lbs. Has benefitted greatly since we changed over to simparica. We moved five years ago to a two-acre property in a forest preserve

My Adult dog weighing in at 77lbs. Has benefitted greatly since we changed over to simparica. We moved five years ago to a two-acre property in a forest preserve area. We tried several brands including Comfortis. None were as effective as Sim. Chewy has been our go to place to order! Fantastic customer seevice! Has been faithful to ship on tome! However, the price is now close to $100. This will be my last order regarding this product with your company. I simply cannot afford to pay this at the moment (especially since we are with one income and not two) Seems to me you guys could re evaluate and do better on price. $16 per pill for 6 pills! Please consider reviewing your prices. Suggestion: how about purchase the first box of 6 then get one half price? This time no dog food, no dasaquin purchase nothing but simpirica at $98. I cancelled all other purchases and you guys lost money. It makes me wonder how many others have cancelled additional purchases due to price issues?

Rated 5 out of 5 stars
By Barbara on Aug 1, 2025

Fast processing and quick delivery.

Only product that we've found works 100% plus. You can actually give to pet every other month because it seems to stay in their system longer than expected. Plus,

Only product that we've found works 100% plus. You can actually give to pet every other month because it seems to stay in their system longer than expected. Plus, because the dogs are protected, the cats don't get fleas either. Truthfully we haven't had fleas on pets or in home 4 years now.

Rated 4 out of 5 stars
By Lauren on Apr 4, 2025

Keeps fleas at bay, but not off your dog

I don’t enjoy giving my dog these pills because of the associated risk of seizures, but I live in a pseudo tropical environment so it’s a necessary step. I recently

I don’t enjoy giving my dog these pills because of the associated risk of seizures, but I live in a pseudo tropical environment so it’s a necessary step. I recently found a flea in my dog’s ear - it was a reminder that this doesn’t repel fleas, it kills them after they bite. I’m thinking of switching up products to something that repels them too. I don’t like using any of these chemicals, but I also don’t want my dog to have fleas and ticks. No really good solution that I know of except for moving to a colder climate.

Rated 5 out of 5 stars
By Madi on Nov 27, 2018
Top 500 Contributor

Thank You!

I can't speak highly enough about this! My dog has been on topicals her whole life then once we moved in to this new complex, her treatment suddenly stopped working

I can't speak highly enough about this! My dog has been on topicals her whole life then once we moved in to this new complex, her treatment suddenly stopped working. She developed a severe flea allergy which then led to skin infections. I was skeptical at first using oral tablets but my vet insisted we give this a try. Within just a couple of weeks, the fleas disappeared! It's been 3 months and we haven't seen one since. Ordering online was super easy too. My vet loves working with Chewy and happily approved the order right away. :)

Rated 5 out of 5 stars
By Carissa on Aug 27, 2025

Immediate relief!

We recently moved 1/2 way across the country and due to the different climate and a lot of crazy looking bugs and swarms of mosquitoes, we needed additional protection

We recently moved 1/2 way across the country and due to the different climate and a lot of crazy looking bugs and swarms of mosquitoes, we needed additional protection for Masha. This did the trick! She will even take it like it’s a treat! Easy peasy. We highly recommend it.

Rated 5 out of 5 stars
By dsweat on Jul 10, 2020

The Best product ever!

I've used this product before and was very happy with it. Did without it for awhile because it was cost effective,(High priced). I've tried everything else and nothing

I've used this product before and was very happy with it. Did without it for awhile because it was cost effective,(High priced). I've tried everything else and nothing was working so I went back to Simparica because I knew how effective it was. For the price it's worth it! After giving it to her within 6hours I could see the fleas dying and coming off of her. It was amazing how powerful this works! I will not use anything else.

Rated 5 out of 5 stars
By Corene on Nov 29, 2025

Best flea and tick product

Simparica has always kept our dogs free from any issues with fleas and ticks. We are outside and hiking in the mountains so they are always exposed to fleas and

Simparica has always kept our dogs free from any issues with fleas and ticks. We are outside and hiking in the mountains so they are always exposed to fleas and ticks. Any ticks found are always dead and never engorged. None of our dogs have had any reactions. We habe 2 adult German Shepherds and a senior Australian Cattle Dog.

Rated 5 out of 5 stars
By Cheyenne on May 27, 2020

Loved it. Highly recommend it

There was one part by the garage that had really bad fleas surrounding it and my dog always ran through it (he has free rang of the yard) and he ended up getting

There was one part by the garage that had really bad fleas surrounding it and my dog always ran through it (he has free rang of the yard) and he ended up getting covered horriblely. We had tried colors and other treatments before this and this killed all his fleas in a day, he's completely treated all his fleas are gone! I'm a bit confused by everyone talking about the price I got mine from thrive for only $19 but then again it was a single once a month pill.

Rated 5 out of 5 stars
By LyrasMom on Jun 24, 2020

Life Saver!

My girl Lyra is a black lab weighing 52lbs. She has been on this flea and tick treatment for a year now and it’s been excellent. There has been a rare occasion where

My girl Lyra is a black lab weighing 52lbs. She has been on this flea and tick treatment for a year now and it’s been excellent. There has been a rare occasion where I will find a tick on her, but 9 times out of 10 it is dead. I have never found fleas on her either and we have a MAJOR flea problem on our property in AR. My baby is so happy we chose Simparica!

Rated 5 out of 5 stars
By Angela on Aug 20, 2025

Good

Lily has fleas on her body, and she often bites her back and feet. After taking the medicine, she basically doesn’t bite anymore.very good. Thank you!

Lily has fleas on her body, and she often bites her back and feet. After taking the medicine, she basically doesn’t bite anymore.very good. Thank you!