Simparica Chewable Tablet for Dogs, 2.8-5.5 lbs, (Yellow Box), 3 Chewable Tablets (3-mos. supply)

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About This Item

Details

  • 35-Day Flea and Tick Prevention for Dogs: Simparica is a tasty, once-a-month chewable that protects your dog from fleas and ticks for 35 days, even if the next dose is a few days late.
  • Kills 6 Types of Ticks: Proven to kill Gulf Coast, Brown Dog, Deer, American Dog, Lone Star, and Asian Longhorned ticks.
  • Helps Prevent Lyme Infections: FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Fast-Acting Relief: Starts killing fleas within 3 hours and ticks within 8 hours. Kills adult fleas before they lay eggs to help stop infestations fast.
  • Tasty, Once-a-Month Chewable: Pork-liver flavored for easy dosing. Approved for dogs 6 months and older weighing at least 2.8 lbs, and backed by a 100% satisfaction guarantee on prevention.

Ingredients

Instructions

FAQ

Learn More About Simparica From Our Team of Experts

Protects Dogs From Ticks & Fleas for 35 days

Simparica is tasty pork liver-flavored, veterinarian-recommended monthly chew that protects your dog from fleas and ticks for a full 35 days.[1] It works fast and starts to kill fleas in 3 hours and ticks in 8 hours.[2] Simparica is approved for dogs 6+ months of age, weighing 2.8 lbs or more.

FDA-Approved to Prevent Lyme Infections*

Because it kills deer ticks, Simparica is FDA-approved to block infections that may cause Lyme disease. It kills 6 different types of ticks, including:

  • Gulf Coast Tick
  • Deer Tick
  • American Dog Tick
  • Lone Star Tick
  • Brown Dog Tick
  • Asian Longhorned Tick

Satisfaction Guaranteed

Simparica comes with a 100% satisfaction guarantee on prevention—so you can feel confident choosing fast, reliable protection. It’s a simple way to stay proactive about your dog’s care, with support you can count on.

Protect Your Dog & Earn Rewards From Zoetis

Your 6-or 12-count Simparica purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future vet care and more! Learn More at zoetispetcare.com/rewards

About Zoetis, the Makers of Rimadyl

At Zoetis, we’ve helped pets live their best lives for over 70 years. Zoetis offers a comprehensive range of products to support your pet’s health—from pest prevention and pain management to allergic itch relief and more. Know that we’ll always be here for you and your pet, no matter what.

Shop Zoetis

IMPORTANT SAFETY INFORMATION

Simparica is for use only in dogs 6 months of age and older. Simparica, which contains sarolaner, a member of the isoxazoline class, may cause neurologic signs such as tremors, unsteadiness, and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding, or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaPI.com.

*Data on file, Zoetis Services LLC.

References:Six RH, Liebenberg J, Honsberger NA, Mahabir SP. Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ctenocephalides felis on dogs. Parasit Vectors. 2016;9:90Honsberger NA, Six RH, Heinz TJ, et al. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67–72 (AR-04287).

SMP-00748

4.7
Rated 4.7 out of 5 stars
171 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

89% Positive

Effectiveness

87% Positive

Ingredients

83% Positive

Long-Term Benefits

88% Positive

54 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Titus on Aug 3, 2019

Gets the jobs done

Our apartment complex is loaded with flees due to the stray cats. My poor Athena and Sparta were covered in fleas. We could not get them to go away no matter how

Our apartment complex is loaded with flees due to the stray cats. My poor Athena and Sparta were covered in fleas. We could not get them to go away no matter how many flea baths and combs we ran them through. We went to the vet and they were both put on the Simparica. We have not seen 1 flea on either them and it has been 3 months.

By Titus on Aug 3, 2019

Rated 5 out of 5 stars
By Charycebon on Mar 6, 2020

Works Great!!!

My dog is 13 yrs old and we never had a huge issue with fleas where I lived. There were periods of time when he would go to SC and would be infested with them. All

My dog is 13 yrs old and we never had a huge issue with fleas where I lived. There were periods of time when he would go to SC and would be infested with them. All the baths didn't help so I was recommended by his vet to use Comfortis. That was amazing and we didn't have anymore issues until recently. I'm in another state now and I took him to a dog sitter who had him almost two weeks (I was out of the country and couldn't bring him with me). She had several dogs she was sitting at the time including 3 of her own. She told me she gave him a bath, but when I got home that's when I noticed the fleas. I tried to order Comfortis but unfortunately it was declined by my vet because it wasn't in his weight class. My dog is 2.8 lbs and the lowest dosage they have was 3.3 lbs. They recommended Simparica in its place and I haven't had anymore issues with fleas!

By Charycebon on Mar 6, 2020

Rated 5 out of 5 stars
By Doris on May 19, 2025

The box

I love that I can get this delivered to my door and Chewy has what I need. He is so little that my vet didn’t carry it there.

I love that I can get this delivered to my door and Chewy has what I need. He is so little that my vet didn’t carry it there.

By Doris on May 19, 2025

Rated 5 out of 5 stars
By Ramya on Mar 20, 2026
Biscotti
Biscotti

So thankful!!!!

Our Korean pom was only 2.4 lbs on arrival at 8 mos old and he didn’t qualify for any oral flea and tick prevention. I focused on getting his weight and size up,

Our Korean pom was only 2.4 lbs on arrival at 8 mos old and he didn’t qualify for any oral flea and tick prevention. I focused on getting his weight and size up, and didn’t realize I hadn’t started him on this yet. We live on a lake and we live in FL and I have had two scares with fleas jumping on him in the yard. The flea shampoos don’t seem to do much. I am very very reluctant to try trio drugs on such small dogs as my pom is only 4.6 lbs now because if they react to the med, I have no way of knowing which of the three he’s reacting to. Since he was doing well on heartgard, I didn’t want to change that either, so we added this in. We had ZERO side effects and will continue. Within a day the one flea I couldn’t grab off him fell dead.

By Ramya on Mar 20, 2026
Biscotti
Biscotti

Rated 5 out of 5 stars
By Yorkiemom on Feb 26, 2019

Worked like a charm!

Worked immediately! Fleas gone! Dogs and mom are both happy! Will purchase again.

Worked immediately! Fleas gone! Dogs and mom are both happy! Will purchase again.

By Yorkiemom on Feb 26, 2019

Rated 1 out of 5 stars
By Barbara on Jun 26, 2025

Doesn’t work

She has been on this for about 6 months and nope she has fleas

She has been on this for about 6 months and nope she has fleas

By Barbara on Jun 26, 2025

Rated 5 out of 5 stars
By bopks on Aug 30, 2020

Just what I needed!

This is one of the very few products that covers small dogs. This flea and tick treatment is a year round must for our midwest weather! Thankfully Chewy had it!

This is one of the very few products that covers small dogs. This flea and tick treatment is a year round must for our midwest weather! Thankfully Chewy had it! They sent it rapidly, new and in original package!

By bopks on Aug 30, 2020

Rated 1 out of 5 stars
By Molly on Mar 27, 2024

Unfortunately not for my dog

Cleo had a super bad reaction, she had multiple seizures and was foaming out her mouth and butt the night she took it. We almost lost her but she purged most of

Cleo had a super bad reaction, she had multiple seizures and was foaming out her mouth and butt the night she took it. We almost lost her but she purged most of it from her system. She couldn’t keep food in her for almost a week after. I’m still working on bringing her weight back.

By Molly on Mar 27, 2024

Rated 5 out of 5 stars
By Mary on Mar 31, 2020

Happy dogs

My vet recommended this product and I really like it. My dogs do well with it and it is easy to hide in their food. They are finicky treat takers so being able to

My vet recommended this product and I really like it. My dogs do well with it and it is easy to hide in their food. They are finicky treat takers so being able to put it in their food has been so easy with this pill. We travel and I love the flea and tick protection with Simparica.

By Mary on Mar 31, 2020

Rated 4 out of 5 stars
By Constance on Jul 25, 2020

SIMPARICA KEEPS MY KIDZ HAPPY & FLEA FREE!!! ;-)

1 of my kids was allergic 2 a different flea med, so I tried Simparica & i was satisfied with it's results. It keeps the fleas away & my kidz happy ;-). If ur

1 of my kids was allergic 2 a different flea med, so I tried Simparica & i was satisfied with it's results. It keeps the fleas away & my kidz happy ;-). If ur not satisfied with ur current flea med, give Simparica a try.

By Constance on Jul 25, 2020