Simparica Chewable Tablet for Dogs, 22.1-44 lbs, (Mint Box), 3 Chewable Tablets (3-mos. supply)

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About This Item

Details

  • 35-Day Flea and Tick Prevention for Dogs: Simparica is a tasty, once-a-month chewable that protects your dog from fleas and ticks for 35 days, even if the next dose is a few days late.
  • Kills 6 Types of Ticks: Proven to kill Gulf Coast, Brown Dog, Deer, American Dog, Lone Star, and Asian Longhorned ticks.
  • Helps Prevent Lyme Infections: FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Fast-Acting Relief: Starts killing fleas within 3 hours and ticks within 8 hours. Kills adult fleas before they lay eggs to help stop infestations fast.
  • Tasty, Once-a-Month Chewable: Pork-liver flavored for easy dosing. Approved for dogs 6 months and older weighing at least 2.8 lbs, and backed by a 100% satisfaction guarantee on prevention.

Ingredients

Instructions

FAQ

Learn More About Simparica From Our Team of Experts

Protects Dogs From Ticks & Fleas for 35 days

Simparica is tasty pork liver-flavored, veterinarian-recommended monthly chew that protects your dog from fleas and ticks for a full 35 days.[1] It works fast and starts to kill fleas in 3 hours and ticks in 8 hours.[2] Simparica is approved for dogs 6+ months of age, weighing 2.8 lbs or more.

FDA-Approved to Prevent Lyme Infections*

Because it kills deer ticks, Simparica is FDA-approved to block infections that may cause Lyme disease. It kills 6 different types of ticks, including:

  • Gulf Coast Tick
  • Deer Tick
  • American Dog Tick
  • Lone Star Tick
  • Brown Dog Tick
  • Asian Longhorned Tick

Satisfaction Guaranteed

Simparica comes with a 100% satisfaction guarantee on prevention—so you can feel confident choosing fast, reliable protection. It’s a simple way to stay proactive about your dog’s care, with support you can count on.

Protect Your Dog & Earn Rewards From Zoetis

Your 6-or 12-count Simparica purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future vet care and more! Learn More at zoetispetcare.com/rewards

About Zoetis, the Makers of Rimadyl

At Zoetis, we’ve helped pets live their best lives for over 70 years. Zoetis offers a comprehensive range of products to support your pet’s health—from pest prevention and pain management to allergic itch relief and more. Know that we’ll always be here for you and your pet, no matter what.

Shop Zoetis

IMPORTANT SAFETY INFORMATION

Simparica is for use only in dogs 6 months of age and older. Simparica, which contains sarolaner, a member of the isoxazoline class, may cause neurologic signs such as tremors, unsteadiness, and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding, or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information at SimparicaPI.com.

*Data on file, Zoetis Services LLC.

References:Six RH, Liebenberg J, Honsberger NA, Mahabir SP. Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ctenocephalides felis on dogs. Parasit Vectors. 2016;9:90Honsberger NA, Six RH, Heinz TJ, et al. Efficacy of sarolaner in the prevention of Borrelia burgdorferi and Anaplasma phagocytophilum transmission from infected Ixodes scapularis to dogs. Vet Parasitol. 2016;222:67–72 (AR-04287).

SMP-00748

4.8
Rated 4.8 out of 5 stars
1508 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

91% Positive

Effectiveness

91% Positive

Ingredients

89% Positive

Long-Term Benefits

92% Positive

479 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 1 out of 5 stars
By Carol on Oct 24, 2025
Sophie
Sophie

May cause seizures!!! Beware!!

I used Simparica for years for all of my dogs. However I suspect (and have read reports) that it contains ingredients that can cause seizures in dogs. Unfortunately

I used Simparica for years for all of my dogs. However I suspect (and have read reports) that it contains ingredients that can cause seizures in dogs. Unfortunately I was unaware of this in time to prevent my dogs from being exposed to it. Both of my dogs developed epilepsy. They are two different breeds and were otherwise healthy until they were given Simparica for an extended period (over two years). Both my vet and my neurologist confirmed that this is a growing issue with this product. Unfortunately once a beloved pet develops epilepsy it is not reversible. One of our dogs died in our arms during a seizure. The other must have her medicine every 6 hours or she will start seizures. We have switched to a natural flea prevention (available through CHEWY) which has been very effective and was recommended by our neurologist.

By Carol on Oct 24, 2025
Sophie
Sophie

Rated 5 out of 5 stars
By MiniBritt on Jul 11, 2023

Tried - Reluctantly - Glad I finally tried this product

I recently moved from Alaska to Texas with 5 dogs. Along with all of the changes in climate, we had to deal with FLEAS! My dogs, who never leave my backyard, and

I recently moved from Alaska to Texas with 5 dogs. Along with all of the changes in climate, we had to deal with FLEAS! My dogs, who never leave my backyard, and are not around other dogs, got fleas! Not like an infestation, but a few on each dog. I tried bathing them; I tried spays; I tried having the yard treated. I felt like I had tried everything but oral flea medication. I was so reluctant to try oral flea meds because I've heard so many horror stories about reactions. But I couldn't get even a few fleas under control and my dogs were miserable. One of my boys was even scratching himself raw. So I asked my vet to approve my order of Simparica from Chewy. I held my breath and gave the medication to three of my dogs. By the next day, only one of those three dogs had 1 visible flea, the others were flea free! So, I gave the medication to my other dogs as well. Within 2 days, they were ALL flea-free and we had zero reaction to the medication in any of the dogs! We are now a couple of weeks out from their first dose, and still no fleas. The dogs are so much happier and so am I.

By MiniBritt on Jul 11, 2023

Rated 5 out of 5 stars
By VetTech on Mar 6, 2019
Top 250 Contributor

Product With Results

Working at a vet, you learn a lot about the different products out there for your pet. Some are money well spent, and others not so much. Well this one happens to

Working at a vet, you learn a lot about the different products out there for your pet. Some are money well spent, and others not so much. Well this one happens to be affordable and worth it! Obviously every pet is different and everyone gets different results, but I personally use this for my pups, and have been very pleased with it. One reason I love it is because it’s way more convenient than the liquid applications. These come in tablets that your dog takes by mouth, and it helps get rid of existing fleas, and works as a great preventative. Another bonus is that my dogs enjoy this like a treat. This is a prescription item, so you will need vet approval before your order officially goes through, but it’s quite simple. You just place your order, Chewy will reach out to your vet, and once they get the ok from them, they’ll ship your item. I received my item 2 days after my order was placed, and it was a wonderful experience overall. I love Chewy pharmacy, and I’ll be ordering again through them. I love Chewy as is, but when they started their pharmacy, I was ecstatic!

By VetTech on Mar 6, 2019
Top 250 Contributor

Rated 5 out of 5 stars
By Beverly on Apr 30, 2026
Pompey
Pompey

Peace of Mind

On the advice of my veterinarian my pug was switched from a collar to Simparica, because the ticks were bypassing the collar and my boy got anaplasmosis AND Lyme

On the advice of my veterinarian my pug was switched from a collar to Simparica, because the ticks were bypassing the collar and my boy got anaplasmosis AND Lyme. On the Simparica, I know the ticks will die if they attach and I won't miss finding a tiny one that might have gone into my pug's ear or lodged within his coat.

By Beverly on Apr 30, 2026
Pompey
Pompey

Rated 5 out of 5 stars
By Kathleen on Jul 31, 2025
Peaches
Peaches

Quick and easy ordering and delivery

It really works. My dog and I go outside several times a day and visit parks with other dogs, grass, trees and other greenery, she's had no ticks or fleas or other

It really works. My dog and I go outside several times a day and visit parks with other dogs, grass, trees and other greenery, she's had no ticks or fleas or other parasites on her at all while using this preventative treatment. She tolerates the tablets with ease and readily takes it when given.

By Kathleen on Jul 31, 2025
Peaches
Peaches

Rated 5 out of 5 stars
By Rick on Sep 21, 2019

Fantastic chewable pill

Have been giving this pill to my dog over 7 years and no fleas or ticks. If I find a tick on him it is dead. Only give to my dog once a month. Chewy was great getting

Have been giving this pill to my dog over 7 years and no fleas or ticks. If I find a tick on him it is dead. Only give to my dog once a month. Chewy was great getting this to me in just a few days.

By Rick on Sep 21, 2019

Rated 1 out of 5 stars
By tina on Jan 29, 2025

Didn't receive the right medication

I was sent the wrong heartworm and flea preventative I called and asked for a return or if they could send me a new one because it was not filled right and was told

I was sent the wrong heartworm and flea preventative I called and asked for a return or if they could send me a new one because it was not filled right and was told no had to wait for a label label still has never come and I had to go back to my original veterinarian in order it and now I'm out a hundred and something dollars because I'm still waiting for a label that never came and I couldn't get the right one sent to me until that was sent back and No label has come everybody told me oh chewy is great chewy has been great no it has not my forte take of it and it was the very first time is it's not worth the hassle

By tina on Jan 29, 2025

Rated 4 out of 5 stars
By Martin on Dec 9, 2019

Excellent Product/Ridiculous Price Increase

I love this product but am totally confused by the recent increase in price from $68 to $91 for package of six. Also I just received an email from the Chewy Pharmacy

I love this product but am totally confused by the recent increase in price from $68 to $91 for package of six. Also I just received an email from the Chewy Pharmacy explaining that the price increase is due to the Mfg. and offering a 15% reduction in price to be included in my next auto-shipment in June 2020. Sounds great except the 15% price reduction offer expires 3/7/2020. Is this a joke?

By Martin on Dec 9, 2019

Rated 5 out of 5 stars
By Katie on Apr 8, 2019

Great Product so far

I switched to Simparica from Nexgard per my vet's recommendation in Decemeber 2018. I stopped giving it in January and just started again last week.I chose this

I switched to Simparica from Nexgard per my vet's recommendation in Decemeber 2018. I stopped giving it in January and just started again last week.I chose this over Nexgard this year because the weight ranges are smaller than Nexgards, and fit my dog better.My dog has only had this 3 times, but I haven't found any ticks on him nor has he had any reactions to it. I usually get it from my vet so this was my first time ordering medication from Chewy. Chewy needed to get the prescription from my vet, which they were able to get the same day I ordered, and still ship it out that same day, which impressed me. I will keep using Chewy because it's easier than going to the vet.

By Katie on Apr 8, 2019

Rated 5 out of 5 stars
By Vicky on Mar 21, 2024

A great flea & tick prevention

Both of our long hair dachshunds use the Simparica. One uses the Simparica Trio because he’s allergic to the heart worm preventing shot the other takes regular Simparica

Both of our long hair dachshunds use the Simparica. One uses the Simparica Trio because he’s allergic to the heart worm preventing shot the other takes regular Simparica since she takes the heartworm prevention shot. Simparica works great for both of them. With dogs on all sides in our neighborhood we need a good flea & tick prevention, Simparica does the job

By Vicky on Mar 21, 2024