PROIN ER (phenylpropanolamine hydrochloride extended-release tablets) for Dogs, 38-mg, 30 tablets

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About This Item

Details

  • A Trusted Veterinarian-Prescribed Solution: Proin ER is the only once-a-day FDA approved medication for the control of Urinary Incontinence due to the urethral sphincter hypotonus in dogs.
  • Consistent Control: Patented extended-release technology provides controlled release that ensures steady absorption, reducing accidents caused by Urinary Incontinence.
  • Clinically Proven Effectiveness: In a 6-month study, dogs taking Proin ER had an 85.6% reduction in average daily Urinary Incontinence incidences compared to baseline.
  • Tailored Strengths for All Sizes: Available in 18mg, 38mg, 74mg, and 145mg tablets to accomodate your dog's weight and dosage needs. Use only as directed by a veterinarian.

Ingredients

Instructions

FAQ

Learn More About Proin ER From Our Team of Experts

These Proin Extended-Release Tablets have the same efficacy as Proin Chewable Tablets.

If You Like PROIN, You’ll Love PROIN ER

PROIN has been trusted by veterinarians for nearly 15 years to safely and effectively treat urinary incontinence (UI) due to urethral sphincter hypotonus in dogs. Now, there’s PROIN ER — a canine UI medication that’s just as effective as PROIN with only one pill a day.

Signs of Urinary Incontinence

  • Dripping, leaking urine 
  • Wet spots where the dog sleeps
  • Excessive licking of genitals
  • Red, irritated skin in the genital area

About PROIN ER

PROIN  ER (phenylpropanolamine hydrochloride extended-release tablets) employs patented technology to help reduce involuntary urine leakage in dogs, all in a once-daily dose. Ask your veterinarian before using PROIN  ER with any other medications.

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Important Safety Information

PROIN ER IMPORTANT SAFETY INFORMATION: For oral use in dogs only. Not for human use. Keep out of reach of children. If accidentally ingested by humans, contact a physician immediately.

The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases death, including euthanasia has been reported. Sudden death was sometimes preceded by vocalization or collapse.

Instances of dogs chewing through closed vials of PROIN and eating the vial contents have been reported, in some cases resulting in overdose. Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN Chewable Tablets or PROIN ER tablets. Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN Chewable tablets or PROIN ER tablets.

PROIN and PROIN ER may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure. Dogs may transition from PROIN Chewable Tablets to PROIN ER without a break in administration. However, do not alternate PROIN ER with PROIN Chewable Tablets because the effectiveness and safety of interchangeable use have not been evaluated.

The safe use of PROIN and PROIN ER in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens, or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions or visit prnpharmacal.com.

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4.7
Rated 4.7 out of 5 stars
2168 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

88% Positive

Effectiveness

87% Positive

Ingredients

87% Positive

Long-Term Benefits

86% Positive

795 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 2 out of 5 stars
By Dora on Mar 25, 2026

NOT GOOD

I'm having an extremely difficult time getting Bruiser to take them. I've tried wrapping them in lunch meat, cheese, smearing peanut butter on them and nope, wont

I'm having an extremely difficult time getting Bruiser to take them. I've tried wrapping them in lunch meat, cheese, smearing peanut butter on them and nope, wont take it. My husband was eating a grilled cheese sandwich, cut off a piece and put the pill between the bread and he did eat it but I cant be feeding him grilled cheese sandwiches! As of now I feel $155.20 was wasted. I purchased these March 4, 2026 and hes taken a total of maybe 6, I've even had to toss a couple due to smearing the peanut butter on them. Not to happy with tge product.

Rated 5 out of 5 stars
By Justine on Feb 25, 2026

Works Wonders

Our 7 month old puppy unfortunately has spay incontinence and this pill has worked a miracle. We initially tried alternative medicines like nutrivet bladder control

Our 7 month old puppy unfortunately has spay incontinence and this pill has worked a miracle. We initially tried alternative medicines like nutrivet bladder control and incurin, but those only worked 70% of the time. Our dog wasn’t initially approved for Proin due to high blood pressure, but has since gotten that under control. Proin has worked for her 100% of the time since her first pill. I don’t think one medication is necessarily better than the other, but rather has to do with your individual dog’s condition and needs. I’ve heard incurin worked best for other dogs so it really all depends on your dog. If you’re dealing with a similar issue I say you give this pill a try. We haven’t noticed any side effects with this medication.

Rated 5 out of 5 stars
By tina on Mar 16, 2026

works like a charm

first i used this product my dog had some weird changes going on with her. she was very fearful and very jumpy at any noise. it did work somewhat but i stopped

first i used this product my dog had some weird changes going on with her. she was very fearful and very jumpy at any noise. it did work somewhat but i stopped it . i tryed other medication for her incondinence. had the same problems, but they did not work as well. so, after talking to my vet who said to keep giving it to her it worked out just fine. no more leaks and her body got used to the medication, because she is fine now after a few month taking it.

Rated 4 out of 5 stars
By Erin on Mar 30, 2026

Works well!

I'm pleased that it helps my pup with bladder control. The effectiveness wanes a bit by the evening but as long as we get him outside on a schedule it's fine.

I'm pleased that it helps my pup with bladder control. The effectiveness wanes a bit by the evening but as long as we get him outside on a schedule it's fine. My pup is 70 lbs and needs 74 mg ER + 18 mg ER. He seems to tolerate it well after a year on it.

Rated 5 out of 5 stars
By Toni on Mar 13, 2026

Works!

My senior corgi began having leakage when napping, even with frequent bathroom breaks. Learned this is common with older females due to loss of muscle control. With

My senior corgi began having leakage when napping, even with frequent bathroom breaks. Learned this is common with older females due to loss of muscle control. With the very first pill, we never saw another problem. She’s been on the Proin for 2 months now with no noticeable side effects.

Rated 1 out of 5 stars
By Denise on Jan 27, 2026

They could not get anything right.

I ordered it on December 28, 4 times I gave them the vet info, they kept saying they could not get a hold of the vet, yet I was talking to the vet and the vet said

I ordered it on December 28, 4 times I gave them the vet info, they kept saying they could not get a hold of the vet, yet I was talking to the vet and the vet said they did not want to fill it because I needed to snap the pills in half because my dog was too big for the smaller size and too small for the next. If the vet is saying it’s ok, and I have been giving him his brothers same meds (vet oked), breaking them in half so he gets one and a half and it is working, fill it. Much better to let them run out. And I am sorry, a 10% discount for my time and trouble doesn’t get it. Tomorrow will be one month and I still don’t have it. I am a little angry still.

Rated 5 out of 5 stars
By Barbara on Apr 3, 2026

Keeping things clean

Our 30-pound, 12-year-old dog was starting to have pee dribbles, so I asked our vet about it and she prescribed Proin ER. This has been keeping her from dribbling

Our 30-pound, 12-year-old dog was starting to have pee dribbles, so I asked our vet about it and she prescribed Proin ER. This has been keeping her from dribbling for almost a year now.

Rated 5 out of 5 stars
By Jen on Dec 28, 2025

Sadly my dog needs this to control incontinence

Fawn most likely had a nerve knicked during spay surgery at a shelter, she’s the second rescue thats happened to in my life. So I have to give her proin daily to

Fawn most likely had a nerve knicked during spay surgery at a shelter, she’s the second rescue thats happened to in my life. So I have to give her proin daily to control it. Its fantastic! Shes really deep and shy and peeing herself is very obviously embarrassing to her, when she wales up wet she will jump up and go hide. My poor girl. When we give her proin every night before bed she has zero accidents. The only problem is dosing with this medication. Shes an 80lb white German Shepherd and supposedly her dose is 145mg, but the vet said with this med its trial and error till you get the dose right. And he was right!! But remember I buy the extended release so its a bit higher - but I take a 145mg pill and cut it into 6 small pieces! All she needs is one - so her actual dose is about 25mg. When I gave her the whole 145mg the first day by the doctors orders, Fawn couldnt get up, couldnt walk, couldnt eat or drink or even open her eyes bc her third eyelid was sooo exposed. It was terrifying and we immediately cut the pills up to give her the smallest dose possible and that ended up being about 25mg. So yes it works, she’s still a baby and will need to take this for life, just like our previous German Shepherd who lived on it daily for 14 years. Side effects could include weight gain so exercise is a must.

Rated 5 out of 5 stars
By Andrea on Feb 13, 2026

Pee meds

My pup Indy a weimariner. Was having incontinent problems and having accidents in the living room on the carpet after she was on this for probably 3 or four weeks

My pup Indy a weimariner. Was having incontinent problems and having accidents in the living room on the carpet after she was on this for probably 3 or four weeks. She's been doing , so good.. she will definitely have it for as long as she needs it. And the price is reasonable. Trust me I shopped around.

Rated 5 out of 5 stars
By Alice on Mar 9, 2026

Extended release formula

I was giving Molly a morning and evening tablet. With this extended release version, she only needs one a day (sorry Molly, no pill pocket treat in the morning@)

I was giving Molly a morning and evening tablet. With this extended release version, she only needs one a day (sorry Molly, no pill pocket treat in the morning@). And I'm paying half as much, so that's great too!