Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count bottle

Juanita started to show elevated liver numbers on March 23, and even the vet thought she wouldn't make it. So we started Denamarin one hour before breakfast (as it is recommended to have empty stomach, one hour prior to meal or two hours after) twice a day for two weeks and then once daily since then. Because she was having a crisis that could be caused by a tumor or something else, we tried "Hepar comp." from Heel (a German homeopathy product), injected once every other day with the dose recommended by a vet, until we finished ten ampoules (about three weeks). After that, we have been just maintaining Denamarin, Royal Canin Hepatic mixed with fresh food that I cook for her and her 10-year old sister. So in summary, between April 12 and June 26 her ALT reduced from "244" to "96", her ALP was "1702" on March 23, reduced to "987" in April 12 and last time we checked in June 26 it was "336". Still high but the recovery was impressive for a 13-year old lab. Although we're not sure which specific treatment is working, our vet advised us to continue with the current regimen. Despite the possibility of a tumor, the medication has provided her with quality time and happiness, and we are grateful for the time we get to spend with her.

Vet recommended Denamarin after bloodwork for my 10yr old dog showed some higher range liver values, particularly his ALT and ALP. Checked back in after giving him this for a month, and the levels have decreased slightly. His ALT went from 207>161 (-46) and ALP from 656>545 (-111). Definitely acknowledge that this isn't a complete fix-it for whatever underlying issue is causing these values to go so high, but happy that it does show some effectiveness and helping protect his liver. The tablets are on the larger side and I give it to him in a pill pocket every morning an hour or so before breakfast. He hasn't had any adverse reactions to the Denamarin either. My main criticism is the pricing, as it is unfortunately on the more expensive side and has already increased in price since I bought it last. I may consider looking into other alternatives that contain the same active ingredients if it continues to go up.

Ever since my 9 YO Pitbull mix turned 7, she has had fluctuating ALT #s in her bi-yearly bloodwork checkups, averaging anywhere from 145 - mid 200s. She got her bloodwork done recently in April 2024 and it was back in the 200s, and we still have no idea what is causing the spikes (she even got an ultrasound on her stomach and everything, including her liver, looked good and normal). Vet recommended putting her indefinitely on Demamarin to see what would happen. After 17 days of use, my dog’s ALT dropped from 215 back to 145 (high end of the normal range is 125). Thankfully my dog is basically a ‘garbage disposal’ so eating things has never been a problem for her.. she will inhale her pill with just a little peanut butter on it, no problem! With that quick of a numbers turn around, I have and will definitely be continuing this supplement with her here on out.

I have a 12 year old lab who was diagnosed 2 years ago with GOLPP. This is similar to ALS in humans. Mind works, but body degrades slowly. She was also at that same time put on daily max dose of Rimadyl for her arthritic knees. I read up on the Rimadyl doses causing liver damage when used at regular doses so I knew that this was not something I needed for my lovely Athena. I saw where Denamarin for the liver support was supposed to be off the charts. Sure enough. I took her in just last week for some other issues (that I thought would turn out to be pancreatic and they ended up being an intestinal infection! Whew) and they did a complete blood work on my lab. The vet said, wildly enough for even a senior labrador, she had all within normal range lab work come back . I told her I had the dog on Phibro Cholodin for the GOLPP to help with hind end weakness and nerve damage and also this Denamarin which she was only familiar with the Denamarin. She really was impressed with the labs coming back so high in range. That was good news. I am glad Chewy got it back in stock. We had run out of Denamarin about a month ago and the labs still came back within normal ranges. Testament to the supplement!