Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Small Dogs & Cats, 30 count bottle

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About This Item

Details

  • Support your dog’s liver health with veterinarian-recommended Denamarin.
  • Denamarin for dogs contains S-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione—one of the liver’s main detoxifying agents.
  • The silybin (a bioactive component of milk thistle extract) found in Denamarin is more bioavailable than standardized milk thistle extract.
  • The liver, one of your pet’s most vital organs, is responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system.
  • Denamarin undergoes thorough quality inspections to ensure your dog receives a safe, high-quality product.

Ingredient Information

Instructions

FAQ

Learn More About Nutramax From Our Team of Experts

Combined Power of SAMe and Silybin

Denamarin combines the power of S-adenosylmethionine (SAMe) and silybin to help support healthy liver function in pets.

#1 Veterinarian Recommended

Denamarin is the #1 veterinarian recommended liver support brand.

*Survey conducted among small animal veterinarians who recommended liver support supplements.

The Denamarin Difference

The Silybin (a bioactive component of milk thistle extract) found in Denamarin is more bioavailable than standardized milk thistle.

Unmatched Quality

Each batch of Cosequin undergoes rigorous quality inspections, ensuring that your pet receives a high-quality joint health supplement.

About Nutramax

Family owned and operated since 1992, Nutramax Laboratories exceeds the industry standard for animal health supplements. We develop high-quality products for joint, liver, digestive health, and overall wellness.

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Questions & Answers

35 Customer Questions


When will have this medicine ?

Answer by MildredJun 07, 2022
You can get the one for cats and dogs 12#. It has directions for over 12#

My girl takes denamarin, but it always came in a box, medium size canine dose. Why r they different in the bottle? Are they the same?

Answer by HueyAug 17, 2025
Check the ingredients and the amount of milligrams in each. Please make sure that the former medicine that came in a box is the exact ones. There is an "improved" chewable tablet. Depending on the instructions of the Vet, make sure that you are giving your pet the exact medication, as well as dosage.

Can this be administered in a pill pocket for my cat? She is hard to pill


Will this help decrease elevated ALT and ALP levels?

Answer by ChewyJun 12, 2018
Denamarin is a liver support supplement rather than a pharmaceutical product. Due to this, and the fact that every pet and it's needs is unique, Nutramax cannot guarantee efficacy.

4.6
Rated 4.6 out of 5 stars
1965 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

87% Positive

Effectiveness

88% Positive

Ingredients

87% Positive

Long-Term Benefits

89% Positive

815 Customer Reviews



Rated 5 out of 5 stars
By Judy on Mar 26, 2025

Miracle Drug!

I have a 17 1/2 year old Maine Coon mix that I rescued when he was 3 weeks old. The last few years he’s had bouts of reverse sneezing/coughing and would sometimes

I have a 17 1/2 year old Maine Coon mix that I rescued when he was 3 weeks old. The last few years he’s had bouts of reverse sneezing/coughing and would sometimes just for lack of a better word “violently” throw up-sometimes just food; sometimes liquid; sometimes both. Plus about a year ago he started this strange vestibular thing where he would yowl which always indicated a big puke was coming. He would stumble around, fall over, walk into the wall, etc then be lethargic for a bit then eat as if nothing had happened. It was terrifying. Clavamox or Azithromycin was good at clearing up the upper respiratory. I have another 11 year old that had horrible stomatitis and had a full mouth extraction several years ago so both have regularly gone in for Wellness checks every 3-6 months. Both have been borderline hyperthyroid occasionally but the vet never started them on meds. 2 months ago, my MC, Horton, threw up a lot for 2 days. The second day after his episode he got really lethargic and didn’t snap out of it. Wouldn’t eat or drink. So rushed him to the vet who did “in-house” bloodwork which I don’t trust. He said his T4 was borderline hyperthyroid again, and his liver enzymes were high at 433, and he wanted to put him on methimazole. Plus he gave fluids. I wanted to get a 2nd opinion so I took him to a really good vet out of town. She did more bloodwork and sent it out plus gave him an injection of Cerenia. The next day she called and said she was “very worried about Horton.” His liver enzymes were over 1900! And other numbers weren’t so good either. She recommended to euthanize. I was crushed. I didn’t mention he is over 15 lbs, looks great and hadn’t been coughing or sneezing for some time. My daughter came over and saw how he still looked so healthy, and she said, “Mom, not yet. You’ll know when it’s time, and I think you’ll regret doing it now.” So, I jumped online and Googled “liver support”, and Denamaren was one of the first things I read about. Great reviews; no prescription needed and was affordable. Downside is he HATES taking meds; this isn’t a tiny pill, plus you can’t give with food or cut it or crush it. I called my regular good vet who was back from vacation and asked what she thought and after seeing his numbers she said it was worth a try. So I ordered it really fast and started him on the one for cats and small dogs. His weight actually called for 2 per day, but my vet said to just give 1 per day. So at first he had to be safety pinned snuggly in a blanket with just his head sticking out and his bum against the wall and pill popped followed by about 1/3 syringe of tuna juice water to wash it down. (dry pilling can cause serious esophageal problems) I am not lying when I say for a solid month he only threw up ONCE, and it was just a small hairball. Plus I got every single pill down him. (now he is used to it and doesn’t thrash around at all). The vet said to give for 2 months then we’d do another checkup. He did throw up one more time, but I had given him a new wet food and apparently that was why. Monday he had his checkup. Today the vet called with wonderful news! ALL of his numbers were normal!! Even his T4 was good! She said she was absolutely amazed and thrilled. We are going to keep him on one a day. The routine is to feed then pull his food for 2 hours. Then he gets his pill and about 1/4 c of tuna water. Then an hour later he gets his food again. I start this about 5 am as my cats are grazers, and they’d keep me up all night if no food was out. Yes they are spoiled. Anyway, I cringe to think I could have either had to start him on methimazole for life or PTS. I also want to cry when I think of other kitties I have had that had similar issues that probably could have been saved. I know this is LONG, but if even one more furbaby is saved it’s worth it. My vet is definitely now a fan, and I will recommend it to all my friends who have kitties with similar issues.


Rated 5 out of 5 stars
By Marilyn on Sep 28, 2025

My pets improvement.

Coco slowly improved over 5-7 days of starting medication.. Her heavy breathing came back to normal although she is still struggling to gain her full appetite

Coco slowly improved over 5-7 days of starting medication.. Her heavy breathing came back to normal although she is still struggling to gain her full appetite. Doing Prednisone to enhance her wanting to eat. It is a long struggle.. I want my baby to come back to normal health some days she shows signs other kinda iffy. Prayers for Coco, she is 15 yr old. Bless her little heart.


Rated 5 out of 5 stars
By Amanda on Dec 31, 2025

Helped liver enzymes for our kitten with dry FIP

My daughter’s little guy Ravioli was diagnosed with dry FIP at one year old. Liver enzymes being off the charts was one of his concerns. This in conjunction with

My daughter’s little guy Ravioli was diagnosed with dry FIP at one year old. Liver enzymes being off the charts was one of his concerns. This in conjunction with vet prescribed antivirals, appetite stimulant, and sub-q fluids saved his life. At his 6 month post-diagnosis check up, everything was beautiful with liver enzymes still ever so slightly elevated. We’ve kept him on this medicine to help support his liver further and hope to be able to wean in another month or two. Grateful for this med and for chewy getting it to us promptly when we need it.


Rated 5 out of 5 stars
By Melissa on Apr 4, 2025

Working good so far?

My cat just started using these, they're a little big so my cat doesn't enjoy getting pilled with them but they do fit in churu bites and she eats them up.. so I'll

My cat just started using these, they're a little big so my cat doesn't enjoy getting pilled with them but they do fit in churu bites and she eats them up.. so I'll be stocking up on more churu bites when I get paid! Hoping this helps my cat and it brings her liver enzymes down. Vet recommended this medication so will try to remember to update my review once she's had it for awhile! :)


Rated 5 out of 5 stars
By Krista on Nov 2, 2018

This product is amazing!

My cat Peanut was diagnosed with severe liver disease in December of 2016. The prognosis was not good. He is my best friend and I couldn’t imagine my life without

My cat Peanut was diagnosed with severe liver disease in December of 2016. The prognosis was not good. He is my best friend and I couldn’t imagine my life without him. I was willing to try anything. The doctor prescribed Denamarin. I ordered from Chewy because the price was great and free shipping to boot! I love that you can have it auto shipped. One less thing to remember, which I really appreciated. He pulled through the liver scare and then... This past March, Peanut was diagnosed with cancer and only given a couple months to live at most. It is now November and he is still here with me. I have decided not to give him any meds because his cancer is in his mouth and don’t want to cause him any extra pain or discomfort. I truly feel the Denamarin kept him alive and gave me extra time with my best buddy. I am so thankful for Chewy for making it affordable, easy to order and easy shipping. I feel like they genuinely care about my four legged family members!


Rated 5 out of 5 stars
By Roger-Cyndy on May 12, 2018

Denamarin was quite literally a life-saver.

We initially got this from our Vet for Rascal, our 3 year old Maine Coon Cat, who had Triavitis (combined inflammation of the liver, pancreas & gall bladder). He

We initially got this from our Vet for Rascal, our 3 year old Maine Coon Cat, who had Triavitis (combined inflammation of the liver, pancreas & gall bladder). He was one sick little kitty. He was vomiting... even water, and had stopped eating for two days. Blood tests showed his pancreas and liver enzymes were off the charts. He required 4 days of hospital care with IV antibiotics and was put on Denamarin, which treats the inflammation of Triavitis. During that time our 4 year old cat, Shadow, was in for a routine checkup and we asked for his counts to be checked. His liver counts were also elevated, but no where near as high as Rascals, so prophylactically he was also put on Denamarin. Within a month his counts were back to normal, and in two months, Rascal's were also normal. We will continue to use the Denamarin as it has no downside. We DID LEARN (according to two Vet newsletters from Cornell (NY) and Tufts(MA) Veterinary Universities (Catster and Cat Watch) that each pill should be immediately followed by water (we use a small syringe and squirt in the water with the pill) because it can stick in a cat's esophagus. Rascal & Shadow now come in, together, each morning for their pill and syringe of water. It has become a routine that they actually look forward to, and we think they know it is helping them feel better, too!


Rated 4 out of 5 stars
By Kathleen on May 17, 2018

Showing some positive results!

I'm hoping I can updated this with great news and 5 stars, but it's too soon to tell. My cat has been in liver failure (most likely cholangeohepatitis)and had been

I'm hoping I can updated this with great news and 5 stars, but it's too soon to tell. My cat has been in liver failure (most likely cholangeohepatitis)and had been slowly decompensating over the past year. That's despite several prescription meds. I know nothing is going to stop the disease, but after the last vet visit, I thought it was goodbye time. Her bilirubin went from 4.5 to 9 :( She also started to look disheveled, weak...and yellow. I didn't want to pill her, and to be honest we follow up with food though its recommended on an empty stomach..BUT...after about three weeks, she started purring more. She has some pink in her yellowish ears. Last night she hunted her feather toy. I never thought I'd see that again! So at the very least, she feels a little better. Cons? I give this to her in the evening and she is less likely to eat in the AM, seeming a little nauseous. If I don't give it to her, she doesn't do this. Following with water is VERY important. I don't know if her values will improve, but if that happened??? A MIRACLE! Nonetheless, seeing my 15 year old feel a little better is a bonus that I'll readily take!


Rated 5 out of 5 stars
By Nancy on Jan 20, 2019

Excellent liver support

My cat is stage 3 kidney disease and his pancreas and liver were both starting to fail. The vet immediately suggested we put him on Denamarin, antibiotics and B-Complex

My cat is stage 3 kidney disease and his pancreas and liver were both starting to fail. The vet immediately suggested we put him on Denamarin, antibiotics and B-Complex by fluid. It’s been one month, and he is long off the antibiotics, but we are doing fluids and The Denamarin daily. His last blood work was amazing, his liver levels are back to normal and the pancrease levels are better. It won’t cure your cat, but it will help give you more time with them. As long as he is not in pain and continues to want to be with me and is having a good quality of life, I will continue to fight for him. The fluids and Denamarin are doing great because we caught it so quickly, so I’m keeping him on both until it’s time to let him go. Thank you for giving me more time with my 18 year old orange Tom.


Rated 1 out of 5 stars
By Alicia on Jul 1, 2025

Arrives in severe heat or damaged

This medication is light and heat sensitive. The last package arrived and sat in severe heat for several hours. It was replaced at no cost. The photos shown are

This medication is light and heat sensitive. The last package arrived and sat in severe heat for several hours. It was replaced at no cost. The photos shown are what I got in place of the overheated package....clearly a known damaged box. You can see it was taped up. Then 3 of the pills are exposed from packaging. These are light sensitive pills so they are now garbage. If Chewy is going to mail heat and light sensitive medications, they should to find a way to do it properly.


Rated 5 out of 5 stars
By Leanne on Apr 24, 2025

New color

I kind of freaked out when I saw the new color. Wondering if I had the right medicine. I’m glad they explained it now in the description. My cat is 18 years old,

I kind of freaked out when I saw the new color. Wondering if I had the right medicine. I’m glad they explained it now in the description. My cat is 18 years old, she has hyperthyroidism, kidney failure, she is diabetic and most recently she almost died from Inflamed liver ducts. She has had no problem now taking this and another medicine for her gallbladder. This pill should not be crushed. It has a protective coating to keep it hole until it gets to where it needs to distribute. It’s a pretty decent size pill for a cat to take so there’s not much you can do except manually put the pill down their throat. There are pill shooters if you’re not comfortable with that. I am glad that they changed the blue coating because if I didn’t get the pill down her on the first try, my fingers were blue all day. However, the new pill doesn’t seem to have a slippery coating at all so it’s actually harder to get the pill down.