Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count

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  • All Lifestages
  • Large Breeds

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About This Item

Details

  • Support your dog’s liver health with veterinarian-recommended Denamarin.
  • Denamarin for dogs contains S-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione—one of the liver’s main detoxifying agents.
  • The silybin (a bioactive component of milk thistle extract) found in Denamarin is more bioavailable than standardized milk thistle extract.
  • The liver, one of your pet’s most vital organs, is responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system.
  • Denamarin undergoes thorough quality inspections to ensure your dog receives a safe, high-quality product.

Ingredient Information

Instructions

FAQ

Learn More About Nutramax From Our Team of Experts

Combined Power of SAMe and Silybin

Denamarin combines the power of S-adenosylmethionine (SAMe) and silybin to help support healthy liver function in pets.

#1 Veterinarian Recommended

Denamarin is the #1 veterinarian recommended liver support brand.

*Survey conducted among small animal veterinarians who recommended liver support supplements.

The Denamarin Difference

The Silybin (a bioactive component of milk thistle extract) found in Denamarin is more bioavailable than standardized milk thistle.

Unmatched Quality

Each batch of Cosequin undergoes rigorous quality inspections, ensuring that your pet receives a high-quality joint health supplement.

About Nutramax

Family owned and operated since 1992, Nutramax Laboratories exceeds the industry standard for animal health supplements. We develop high-quality products for joint, liver, digestive health, and overall wellness.

Shop Nutramax

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Questions & Answers

23 Customer Questions

Can this tablet be ground up into a powder?

Answer by Masc • Mar 23, 2026
No, per instructions tablets should given whole, not broken in half or chewed as it reduces the effectiveness of absorption and defeats the special coating to prevent it dosdolving to soon once ingested.

Can the tablet form for large dogs be broken into pieces before administering?

Answer by Masc • Mar 23, 2026
NO. “Denamarin liver supplement tablets should not be broken, crushed, or ground. They are enteric-coated to protect the ingredients from stomach acid and to mask a bitter taste; breaking them reduces their effectiveness.” “Key Considerations for Denamarin Administration: Do Not Crush/Split: The tablet's coating is crucial for efficacy.”

Is this a chewable tablet?

Answer by Chewy • Jun 05, 2022
These tables are chewable.

You suggested splitting the pills if my dog requires 2, am and pm?

Answer by Chewy • Oct 06, 2018
It is recommended to take the suggested dose once a day.
Reviews
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4.6
Rated 4.6 out of 5 stars
1987 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

82% Positive

Effectiveness

85% Positive

Ingredients

83% Positive

Long-Term Benefits

86% Positive

867 Customer Reviews

Rated 5 out of 5 stars
By Mary on Apr 1, 2026

This supplement plus a low copper diet is helping!

This is a great supplement. My dog is impossible to pill, so I hide it in her breakfast and although it’s recommended on an empty stomach, I still think it helps. By

This is a great supplement. My dog is impossible to pill, so I hide it in her breakfast and although it’s recommended on an empty stomach, I still think it helps. By the way, if you’re trying this supplement and still not seeing an improvement in your dog’s liver enzyme values, please consider trying a low copper food like Voyager. The vets will not tell you this! But it is the thing that finally helped my dog’s liver enzymes from continuing to climb to scary levels!

Rated 2 out of 5 stars
By Ronald on Mar 26, 2026

The Price

River is an older dog and her liver enzymes are somewhat elevated. My vet recommended this medication. I won’t know how effective these pills will be for several

River is an older dog and her liver enzymes are somewhat elevated. My vet recommended this medication. I won’t know how effective these pills will be for several months when we do more lab work. River gets two pills a day. A month supply is $154.00 I know a little about medication cost since my dogs are on several different medications. I consider the cost of this medication Price Gouging. I hope it works.

Rated 5 out of 5 stars
By Kathryn on Mar 27, 2026

So glad for a reliable source

We have been using Chewy for a number of the supplements that our aged dogs needs daily and Denamarin is just one of these. I am so grateful for Chewy's auto-shipping

We have been using Chewy for a number of the supplements that our aged dogs needs daily and Denamarin is just one of these. I am so grateful for Chewy's auto-shipping so that I don't have to worry about remembering to fill a prescription. The medicine shows up reliably and one time, leaving me with one less thing to worry about.

Rated 3 out of 5 stars
By Ree on Mar 30, 2026

Damaged boxes

There was no inside packaging like bubble wrap and both product boxes were crushed on one end. Luckily the product was still intact. Don’t know what happened to

There was no inside packaging like bubble wrap and both product boxes were crushed on one end. Luckily the product was still intact. Don’t know what happened to it, but the packers need to be more careful - this has happened on another shipment awhile back.

Rated 1 out of 5 stars
By John on Mar 21, 2026

Expensive and lousy taste.

Very expensive supplement. Along with the high price the tablet is undesirable for my dogs. A flavorful pill would be a great improvement. A lower price would be

Very expensive supplement. Along with the high price the tablet is undesirable for my dogs. A flavorful pill would be a great improvement. A lower price would be greatly appreciated.

Rated 5 out of 5 stars
By DFG on Mar 16, 2026

It's working!!!

Our Luna's liver bloodwork came back bad. Our vet suggested these supplements. Bloodwork done 6 months later...her liver values got better and are stable 6 months

Our Luna's liver bloodwork came back bad. Our vet suggested these supplements. Bloodwork done 6 months later...her liver values got better and are stable 6 months after that.

Rated 5 out of 5 stars
By cindy on Jan 19, 2026

Liver supplement

My 15 year old dog seemed to be ready give out on me. He was not eating, he was very tired, and feeling weak. We took him to the vet to find out he had liver problems

My 15 year old dog seemed to be ready give out on me. He was not eating, he was very tired, and feeling weak. We took him to the vet to find out he had liver problems. We started giving him this supplement for the past month and he's like his old self again. So happy these worked! He's eating whole meals and acts like a puppy again when he runs into the neighborhood dogs.

Rated 5 out of 5 stars
By Ellen on Jan 5, 2026

Chewy, of course, sent it in a box.

This is very important for dogs with elevated liver enzymes. There is only one med Rosy is prescribed that Chewy does not carry, and the vendor persists in mailing

This is very important for dogs with elevated liver enzymes. There is only one med Rosy is prescribed that Chewy does not carry, and the vendor persists in mailing it in padded envelopes so the packages arrive squashed flat. It makes me love Chewy even more, because I don’t have to tell you to box my meds. Everything is boxed when it comes from Chewy. This little jar of Denamarin came in a box, with lots of paper padding. It sad how’s that somebody at Chewy cares.

Rated 1 out of 5 stars
By Karen on Feb 28, 2026

Don't work

My dog has an elevated liver and this does not work For her, I have the I had the prescription one.I tried and also the non prescription.Save your money, maybe for

My dog has an elevated liver and this does not work For her, I have the I had the prescription one.I tried and also the non prescription.Save your money, maybe for some pets.It works but not for mine

Rated 4 out of 5 stars
By Judy on Mar 3, 2026

Quick service

Neither of us are happy about taking the med (it means he’s not healthy) however Chewy makes the necessity a little less painful on the pocketbook and is helping

Neither of us are happy about taking the med (it means he’s not healthy) however Chewy makes the necessity a little less painful on the pocketbook and is helping Murphy to feeling better