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Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Medium Dogs, 30 count

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  • Medium Breeds
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About This Item

Details

  • Support your dog’s liver health with veterinarian-recommended Denamarin.
  • Denamarin for dogs contains S-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione—one of the liver’s main detoxifying agents.
  • The silybin (a bioactive component of milk thistle extract) found in Denamarin is more bioavailable than standardized milk thistle extract.
  • The liver, one of your pet’s most vital organs, is responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system.
  • Denamarin undergoes thorough quality inspections to ensure your dog receives a safe, high-quality product.

Ingredient Information

Instructions

FAQ

Learn More About Nutramax From Our Team of Experts

Combined Power of SAMe and Silybin

Denamarin combines the power of S-adenosylmethionine (SAMe) and silybin to help support healthy liver function in pets.

#1 Veterinarian Recommended

Denamarin is the #1 veterinarian recommended liver support brand.

*Survey conducted among small animal veterinarians who recommended liver support supplements.

The Denamarin Difference

The Silybin (a bioactive component of milk thistle extract) found in Denamarin is more bioavailable than standardized milk thistle.

Unmatched Quality

Each batch of Cosequin undergoes rigorous quality inspections, ensuring that your pet receives a high-quality joint health supplement.

About Nutramax

Family owned and operated since 1992, Nutramax Laboratories exceeds the industry standard for animal health supplements. We develop high-quality products for joint, liver, digestive health, and overall wellness.

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Questions & Answers

30 Customer Questions

So my dog can’t have chicken so he’s been taking these, but is it just the chicken flavor and that’s gonna be OK?

Answer by Bobby • Nov 23, 2025
Please cancel this medicine from my chewy order Denamarine

are these chewable?

Answer by Elise • Feb 02, 2026
My veterinarian says that the pill is very bitter. That's why my miniature schnauzer will only take it with a little peanut butter.

When do you think the Denamarin tablets in?

Answer by Bobby • Nov 23, 2025
Within the next week

I would prefer this to be in chewy form as opposed to the tablet.

Reviews
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4.7
Rated 4.7 out of 5 stars
2603 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

86% Positive

Effectiveness

86% Positive

Ingredients

83% Positive

Long-Term Benefits

86% Positive

980 Customer Reviews

Rated 5 out of 5 stars
Verified Purchase
By Shalma on Mar 18, 2026

Please Read!

This is a fantastic supplement that our vet prescribed for increased liver values. I just want to warn everyone to PLEASE share their dog's detailed diet with their

This is a fantastic supplement that our vet prescribed for increased liver values. I just want to warn everyone to PLEASE share their dog's detailed diet with their doctor and INSIST on analyzing whether that has something to do with the liver values. I consider myself an informed and caring guardian, and I messed up big time, so I want to warn others. We found out our homemade food was NOT balanced (99% of homemade dog food is not; the balance is very delicate!!!), and our beloved girl is being deprived of essential nutrients and vitamins (essentially nutritionally starved) as a result. We even kept a few serving of pre-formulated dry food in her weekly schedule. But that wasn't enough to balance things out. Her liver responded to the imbalanced homemade food by freaking out, despite us thinking we were doing everything right by spending loads buying the best ingredients to cook with for her. PLEASE don't make this mistake! Use pre-formulated food, ALWAYS! You'd be shocked what you can miss and the life-altering symptoms it causes. They can't tell us they feel bad. My dog looks healthy and loved, and yet she's been nutritionally starved due to my well-intentioned attempt to feed her the best food possible. PLEASE consider pre-formulated food, and if you insist on homemade, PLEASE speak with a board-certified vet nutritionist. It's really essential!

Rated 5 out of 5 stars
Verified Purchase
By Lynn on Apr 24, 2026

Improved Liver Panel

Our Minature Schnauser, has suffered a few bouts of pancreatitis-which is expected of his breed. Last spring, I thought we were going to have to put him down. He

Our Minature Schnauser, has suffered a few bouts of pancreatitis-which is expected of his breed. Last spring, I thought we were going to have to put him down. He was so sick, that we ended up at the emergency hospital. They were able to stabilize him over night and he came home later the next day. They started him on Denamarin and advised that he should stay on it for the rest of his life. 6 months later he is at his goal weight, all of his lab work is perfect. We have been getting the drug thru our Vet. I just realized Chewy had it and it’s about $8.00 cheaper each month with auto-ship!

Rated 5 out of 5 stars
Verified Purchase
By Penelope on Mar 30, 2025

Works better than milk thistle alone

My dog was having some high numbers in her liver enzymes, so the vet told me to put her on a milk thistle supplement. I did, but it made her so lethargic. She is

My dog was having some high numbers in her liver enzymes, so the vet told me to put her on a milk thistle supplement. I did, but it made her so lethargic. She is a working dog, so I need her to be active. So the vet suggested I put her on Denamarin. We just started this product and my dog will not eat it,, so I do give it to her in a pill pocket treat. The vet told me to give her the medicine on an empty stomach, so I give it to her an hour before she eats her dinner (no way I can make her wait an hour for breakfast). She seems to have more energy in the day. Now we will see what her next blood work looks like to see if it is working. Fingers crossed!

Rated 5 out of 5 stars
Verified Purchase
By Madison on Sep 1, 2025

Gave me many more years

My dog had very high liver enzymes when she was 15. I’m honored to say that she made it to 19 years old- & her passing had nothing to do with her liver. It kept

My dog had very high liver enzymes when she was 15. I’m honored to say that she made it to 19 years old- & her passing had nothing to do with her liver. It kept her labs within normal range for many years & I highly recommend it, it gave me more time with my favorite furry monster

Rated 5 out of 5 stars
Verified Purchase
By Amy on Sep 22, 2024

Thank you chewy

My dog recently passed away. I had meds that I no longer needed. Kayla is a rep who works there. She made it so I could get a refund, hassle-free. I didn't have

My dog recently passed away. I had meds that I no longer needed. Kayla is a rep who works there. She made it so I could get a refund, hassle-free. I didn't have to go through the stress of returning the meds. She told me not to worry about returning them. She was so compassionate and understanding. To top it all off, they sent me these beautiful flowers as a condolence for having to send my pup to heaven. Thank you so much Kayla and chewy family.

Rated 5 out of 5 stars
Verified Purchase
By elsa on Oct 11, 2025

I think it’s working.

My pup is a bit older and lab shown replicated liver enzymes. MD recommended as treatment. So far her extreme thirst seems to be going back to normal. Have to order

My pup is a bit older and lab shown replicated liver enzymes. MD recommended as treatment. So far her extreme thirst seems to be going back to normal. Have to order labs again in a month will verify then if she is better. I think this is a good treatment so far.

Rated 5 out of 5 stars
Verified Purchase
By WahineHub on May 18, 2020

Unaware But Sure

My 13 year old Jackabee was diagnosed with a bad liver and was told that if she didn't get better that I would have to face putting her down so she wouldn't suffer

My 13 year old Jackabee was diagnosed with a bad liver and was told that if she didn't get better that I would have to face putting her down so she wouldn't suffer. Very disheartened I was sent home with 3 medications and Denamarin. After research on the net, I realized that I wasn't told everything about her condition and quickly found that although the liver is a major organ, it can also regenerate healthy tissues back to liver health. It's been almost 2 months now and my girl is back to her old self. With a strict diet and keeping her on Denamarin faithfully,, she is still with us and is healthy as ever. If your dog is having Liver issues, I would definitely try this. The vet only perscribed it the 1st time over a month ago but thanks to Chewy having them available, it's been a part of her daily diet once a day.

Rated 5 out of 5 stars
Verified Purchase
By Cynthia on Oct 5, 2018

Liver Health

My King Charles Cavalier was diagnosed with Copper Storage disease in October ‘17. Denamarin was prescribed to support his liver health. This is a chronic disease

My King Charles Cavalier was diagnosed with Copper Storage disease in October ‘17. Denamarin was prescribed to support his liver health. This is a chronic disease but manageable. My dog’s quality of life and the prevention of further destruction is possible and very important to me. While my dog is taking other meds to rid the liver of copper and a special diet to prevent additional copper being added to his body, I believe this medication is preventing further erosion of liver itself. His BLOOD LEVELS have improved over the course of this last year. While I have no definitive proof, except for my dog to undergo another biopsy, his appetite, general awarness and energy has showed marked improvement. I would recommend this medication.

Rated 5 out of 5 stars
Verified Purchase
By KatK on Oct 12, 2020

This stuff really WORKS!

My 12 year old chiweenie had some major liver problems going on. He hadn't been sick a day in his life. Then out of nowhere he is having to stay in the animal hospital

My 12 year old chiweenie had some major liver problems going on. He hadn't been sick a day in his life. Then out of nowhere he is having to stay in the animal hospital for 4 nights. His liver numbers were off the charts. They couldn't even get a reading on his ALT it was so high. After only a month on this medication his ALT is 76, which is a bit above normal but WOW it is way back down to nearly normal. Almost unbelievable. I would highly recommend giving this product a try for your dog's liver health. My boy is back to playing and being his normal squirrel chasing self (of course he never comes close to actually catching one ;).

Rated 5 out of 5 stars
Verified Purchase
By Rhonda on Mar 2, 2026

Vet suggested this product

When my dogs liver values were off the vet had me put him on this. He is not keen on it and sometimes giving it an hour before a meal can be difficult but hopefully

When my dogs liver values were off the vet had me put him on this. He is not keen on it and sometimes giving it an hour before a meal can be difficult but hopefully it helps support his liver.