Frontline Shield Flea & Tick Treatment for Large Dogs, 41 - 80 lbs, 6 doses (6-Month Protection)

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About This Item

Details

  • Helps kill ticks, stable flies, chewing lice and adult fleas, flea eggs and larvae.
  • Topical solution helps to repel ticks that may transmit Lyme disease and mosquitoes that may transmit heartworm disease.
  • Helps prevent reinfestation by stopping all flea life stages from developing.
  • Each dose is formulated to protect your dog for a full 30 days.
  • The treatment is easy to apply and is waterproof 24 hours after application.

Ingredients

Instructions

Size

FAQ

Learn More About Frontline Shield From Our Team of Experts

One-Spot Topical Application

Frontline Shield for Dogs is a topical solution that's available without a prescription. From a leading name in flea and tick protection, Frontline Shield is waterproof after 24 hours. 1 dose = 30 days of protection.

Flea, Tick, and Mosquito Facts

  • Fleas and ticks are a year-round threat.
  • They can be brought inside by people or dogs.
  • Fleas, ticks, and mosquitos can transmit harmful parasites and diseases.
  • Just one mosquito bite can spread heartworm disease, causing lifelong damage.

Proven 3-In-1 Protection

Frontline Shield has three active ingredients (permethrin, pyriproxyfen, and fipronil) that kiII fleas and ticks, inhibit egg and larval development of fleas, and repel ticks that may transmit Lyme disease and mosquitoes that may transmit heartworm disease.

How to Apply

Follow these simple steps for a correct and effective application:

  1.  Cut the tip of the pipette with a pair of scissors.
  2.  Part hair and apply on shoulder blades, completely emptying the pipette.
  3.  Leave the protection to spread through your dog's coat.

About Frontline Shield

Frontline Shield for Dogs is a 3-in-1 topical solution that kiIIs fleas and ticks, plus repels ticks that transmit Lyme disease and mosquitoes that transmit heartworm disease. Each dose lasts for 30 days, delivering the lasting protection your dog needs.

Shop Frontline Shield

Questions & Answers

10 Customer Questions


Can I use this around cats


I want to switch topicals. Is there a process to switching from Pet armor to Frontline shield +?


Does this kill mites?


Does this product negate the need for heart worm prevention?

Answer by ChewyMay 25, 2021
This treatment kills fleas and ticks, plus repels ticks that may transmit Lyme disease and mosquitoes that may transmit heartworm disease. That being said, we always recommend consulting your Veterinarian to see what would be the safest for your individual pets treatment plan.

4.4
Rated 4.4 out of 5 stars
501 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

80% Positive

Effectiveness

82% Positive

Ingredients

80% Positive

Long-Term Benefits

82% Positive

166 Customer Reviews



Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 4 out of 5 stars
Verified Purchase
By Cassandra on Jun 21, 2025

Repels both fleas and ticks

Bravecto stopped being as effective on my dog, especially since we are outside a lot and she goes to a doggy day care. Frontline Shield seems better than Bravecto

Bravecto stopped being as effective on my dog, especially since we are outside a lot and she goes to a doggy day care. Frontline Shield seems better than Bravecto now at ensuring any fleas that 'hitchhike' on my dog are killed, the Frontline Shield does it for half the cost of Bravecto and I don't have to coerce my dog into taking an oral (she hates that).


Rated 1 out of 5 stars
Verified Purchase
By Kristine on Oct 13, 2025

Don’t use!

Don’t use this product if you have dogs with sensitive skin. We used the regular formula with no issues last year. This new version is what caused our golden doodles

Don’t use this product if you have dogs with sensitive skin. We used the regular formula with no issues last year. This new version is what caused our golden doodles skin to burn, it gave them a large hot spot where the medicine was administered. And now they are left with a large scabs. I should’ve taken pics when it first happened, but I didn’t think to until it scabbed over.


Rated 5 out of 5 stars
Received Free Product
By Nala on Dec 23, 2023

Got rid of fleas

I used this product on my 50lb husky mix and it worked great! She had never had fleas until we moved into our new home. She loves going into the bushes so we suspect

I used this product on my 50lb husky mix and it worked great! She had never had fleas until we moved into our new home. She loves going into the bushes so we suspect that’s where she got the fleas. There are squirrels and other animals that hang out in the back yard, but within a week we noticed her fleas were gone and it’s been almost 2 months without fleas. Very satisfied!


Rated 2 out of 5 stars
Verified Purchase
By Cindy on Jun 30, 2025

New to this Frontline Shield

Not sure about this new Frontline Shield yet. I only got the 3 month package because last year we had problems with Frontline not working and had a very bad summer

Not sure about this new Frontline Shield yet. I only got the 3 month package because last year we had problems with Frontline not working and had a very bad summer flea infestation. I don't see any fleas on my girl but when I applied it in 3 spots on her back skin like the instructions said it ran all over her hair. After waiting more than the 24 hour period before she went swimming again her hair was still looking greasy from the product. This one is supposed to be stronger and she did seem Tobe irritated by it on the back of her neck and shoulders.


Rated 5 out of 5 stars
Received Free Product
By Mutt on Nov 22, 2023

Great product with great results!

This was my first time trying Frontline Shield. I historically have used Frontline Plus on all of my dogs and have always been pleased with the results. So far,

This was my first time trying Frontline Shield. I historically have used Frontline Plus on all of my dogs and have always been pleased with the results. So far, I’m really liking the added protections that Shield offers. We recently moved to New York; near water and I’ve noticed we have a lot more mosquitoes in the area than I’m used to seeing. I love that Shield offers that added repellent. I’ve also learned that Lyme disease is bad locally so staying on top of my dog’s flea and tick prevention is vital. Luckily, we haven’t had any issues or sightings. Lastly, I’ve tried products in the past that seem to cause my dog localized sensitivity in the application area…I don’t notice that with Shield. All in all, I would definitely recommend this product.


Rated 5 out of 5 stars
Verified Purchase
By Christie on Sep 13, 2025

trustworthy product

I have always trusted Frontline. My dogs are inside/outside and allowed to run freely in a rural environment with field fencing which allows small critters to also

I have always trusted Frontline. My dogs are inside/outside and allowed to run freely in a rural environment with field fencing which allows small critters to also be in their environment. The dogs have never come inside our home with any bugs, etc. on them. I never have to even think about it happening.


Rated 5 out of 5 stars
Verified Purchase
By Elizabeth on Oct 6, 2025

This Stuff Works

We tried the different types of protection that Frontline offered last year, and this one was the one that worked the best for the ticks that were just awful for

We tried the different types of protection that Frontline offered last year, and this one was the one that worked the best for the ticks that were just awful for some reason that year.


Rated 5 out of 5 stars
By Tara on Jan 4, 2022

First time flea

Never dealt with fleas before, and recently I found about 2-3 on my dog. I went to the nearest pet store and picked up frontline shield. This worked like a charm

Never dealt with fleas before, and recently I found about 2-3 on my dog. I went to the nearest pet store and picked up frontline shield. This worked like a charm. Be sure to apply to skin and not fur. I have not seen a flea on him since, and I saw the ones fall off his coat slowly dying/already dead. In addition I got the vets best home spray to spray upholstery to kill the life cycle of any eggs that may be lying around. Cleaned all sheets/clothes on hot, rid his dog bed and now I’m week 4 without seeing a single flea since application. This will kill fleas and prevent them on your dog. In addition, treat any home areas that may have been exposed to flea eggs


Rated 4 out of 5 stars
Received Free Product
By Amber on Nov 30, 2023

Bug free!

Our dog continues to be bug free! She appears to have tolerated this product well. We have not noticed any bad side effects at all. Appears to be a good product

Our dog continues to be bug free! She appears to have tolerated this product well. We have not noticed any bad side effects at all. Appears to be a good product!


Rated 5 out of 5 stars
Verified Purchase
By Jill on Oct 16, 2024

Best flea and tick product

This has been the best way to prevent fleas! I would recommend this over and over again

This has been the best way to prevent fleas! I would recommend this over and over again