Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs, 6 Doses (6-mos. supply)

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About This Item

Details

  • Promotes fast-acting, long-lasting and waterproof protection from fleas and ticks.
  • Each treatment helps protect against fleas and ticks for 30 days.
  • Works to kill adult fleas, flea eggs, flea larvae, chewing lice and ticks.
  • It also helps aid in the control of sarcoptic mange infestations.
  • Formulated with two active ingredients to help disrupt the flea life cycle and prevent new infestations.

Ingredients

Instructions

Size

FAQ

Learn More About Frontline Plus From Our Team of Experts
Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 90 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

Fast-Acting, Long-Lasting Protection

Frontline Plus is formulated with two active ingredients that kill fleas and ticks and prevent new flea infestations from developing. It’s waterproof 24 hours after application, lasts for a full 30 days, and comes in formulas for cats or dogs.

Easy One-Spot Topical Application

Frontline Plus is a spot-on solution that’s available without a prescription. 1 dose = 30 days of protection.

Protects Your Pet

  • Starts killing fleas and ticks fast and protects against reinfestation.
  • Waterproof for a full 30 days starting 24 hours after application.
  • Monthly dosing keeps your dog protected for every season.

How to Apply

Follow these simple steps for application:

  1. Hold upright with foil side toward you and snap applicator tip.
  2. Part hair and apply on shoulder blades, completely emptying the pipette.
  3. Leave the solution to spread through your pet's coat.

About Frontline Plus

To ensure your dog stays protected from fleas and ticks all year round, treat them monthly with Frontline Plus. This simple, easy, one-spot topical solution helps keep your pet free from infestations, providing you with peace of mind.

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Questions & Answers

34 Customer Questions

Can you treat a 4 month old puppy with Frontline?

Answer by Shanquisha.G • Apr 22, 2025
This product can be used on puppies as young as 8 weeks and weighing at least 5 lbs. for small dogs, 23lbs. for medium dogs, 45 lbs. for large dogs, and 89 lbs. for extra-large dogs.

What type of ticks is Frontline effective on? As there are 6 different types of ticks in my area and not all Tropicals cover all 6.

Answer by Chewy • Jun 11, 2019
Frontline Plus treats against Lone Star Ticks, American Dog Ticks, Deer Ticks, Brown Dog Ticks, and Western Blacklegged Ticks.

How long after applying Frontline does it take for fleas and ticks to die

Answer by Chewy • Jul 21, 2019
In a study, FRONTLINE Plus began killing fleas 4 hours after application. Another study showed that within 12 hours, Frontline Plus killed 100% of fleas. This kills fleas and ticks through contact with your pet's haircoat so no biting is necessary. Fleas rise to the top of your pet's haircoat as they die. So, if you start seeing more fleas after treating your pet, consider it a victory for the killing force.

What’s the difference between frontline plus and frontline gold?

Answer by Chewy • Nov 25, 2020
Both, Frontline Plus and Frontline Gold, are effective against ticks, fleas, and lice in both immature and adult versions. The only difference is that Frontline Gold kills fleas faster than Frontline Plus does. Frontline Gold has added a powerful third ingredient, pyriproxyfen which helps to kill the next generation of flea eggs and larvae before they can develop in to adult fleas. Both products require monthly applications and are safe to use in all dogs and puppies above 8 weeks of age.
Reviews
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4.4
Rated 4.4 out of 5 stars
6861 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

81% Positive

Effectiveness

80% Positive

Ingredients

79% Positive

Long-Term Benefits

81% Positive

2794 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Susan on Apr 3, 2026

It Works

I've used this for years on my Pups.....never had a Flea issue and we would be down the shore and back home. Ticks seem to "take a sip" and become freezed dry in

I've used this for years on my Pups.....never had a Flea issue and we would be down the shore and back home. Ticks seem to "take a sip" and become freezed dry in their fur. Though I'm not crazy about putting the medication on them it works.

Rated 4 out of 5 stars
By Diane on Apr 1, 2026

A must for my fur pups!!!

Have always used this and it works. We live in a tick infested environment they need to be treated every spring/summer and they get a lymes vaccinations every year

Have always used this and it works. We live in a tick infested environment they need to be treated every spring/summer and they get a lymes vaccinations every year. I just wish it was not so expensive the price keeps increasing.

Rated 1 out of 5 stars
By Ari on Jan 21, 2026

Used to work

While our pups have been completely fine over the last few years with Frontline. I don’t think I can trust this any longer. It’s not only given one of my dogs a

While our pups have been completely fine over the last few years with Frontline. I don’t think I can trust this any longer. It’s not only given one of my dogs a rash every time we put it on her, we’ve noticed for the last two months (at least) that these are not repelling ticks at all. This was found ALIVE on the bed next to our girls, meaning it had fed and released, and now I’m hoping they don’t get sick. Either these dosages are old, or they changed, because they’re no longer working.

Rated 5 out of 5 stars
By Carol on Jan 29, 2026

It works

My vet had me purchase from them one of those new multi chews. I found a tick crawling in me, several on her, attached and feeding, alive and dead, attached. After

My vet had me purchase from them one of those new multi chews. I found a tick crawling in me, several on her, attached and feeding, alive and dead, attached. After that I went back to the Frontline. I have only ever found dead, unattached ticks, never any fleas and have had no strays wandering around on me. Frontline works on contact with her skin,killing them before they bite. The other only kills them after being bitten and feeding for several minutes.

Rated 1 out of 5 stars
By Traci on Mar 27, 2026

Flea Treatment

Applied treatment to my 3 YO standard poodle, resulting in a chemical burn from his tail to his neck. Have never seen anything like it before.

Applied treatment to my 3 YO standard poodle, resulting in a chemical burn from his tail to his neck. Have never seen anything like it before.

Rated 1 out of 5 stars
By Julie on Feb 25, 2026

Did not work

I used this right after I started seeing fleas after many years with none. It did nothing to help control fleas. I used Advantix II next and it started killing fleas

I used this right after I started seeing fleas after many years with none. It did nothing to help control fleas. I used Advantix II next and it started killing fleas on my dogs right away.

Rated 1 out of 5 stars
By Linda on Dec 23, 2025

Does not work.

I applied this medication a week ago and my dog still has fleas alive inviting her. I shampooed her two days after applying the medication with flea killing shampoo

I applied this medication a week ago and my dog still has fleas alive inviting her. I shampooed her two days after applying the medication with flea killing shampoo. Unfortunately, that has not worked. I shampooed her six days later and she still has a problem. When I comb her, I can find no more than one at a time. In the last three weeks, I have combed approximately five fleas off her, yet after all this she still itches. Frontline is not working and I bought two of them so I am disappointed.

Rated 3 out of 5 stars
By Jesse on Jan 5, 2026

Not sure product is performing optmum

We switched to Frontline liquid from chewable for our dogs some years ago due to acquiring our heeler who has seizures and had learned that chewables may be a seisure

We switched to Frontline liquid from chewable for our dogs some years ago due to acquiring our heeler who has seizures and had learned that chewables may be a seisure trigger for some pets. No noticeable change in the seisure patterns since and rather dismayed that the fall of this year we had found multiple ticks on our dog whole using Frontline liquid regularly.

Rated 5 out of 5 stars
By Deborah on Mar 4, 2026

Chewy is the best

We used this product at the dog rescue so I know that it works and far better than a $400 shot only good for 3 months that they gave her at the vet. without asking

We used this product at the dog rescue so I know that it works and far better than a $400 shot only good for 3 months that they gave her at the vet. without asking me.

Rated 4 out of 5 stars
By Susan on Jan 8, 2026

Quick delivery!

This time was a bit quirky. I’ve had no problems for the many years of getting frontline plus. This time by the time I saw the email about my next shipment, it

This time was a bit quirky. I’ve had no problems for the many years of getting frontline plus. This time by the time I saw the email about my next shipment, it was already being packed up-in about 4 hours. I didn’t need it for another month but wasn’t given the chance to change the delivery date. Always great service prior to this one incident.