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Credelio Quattro/Credelio Quattro-CA1 Chewable Tablets for Dogs, 50.1-100 lbs, 6 Chewables (6-mos. supply)

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About This Item

Details

  • Credelio Quattro/Credelio Quattro-CA1 helps bring peace of mind with the broadest parasite coverage of its kind available to dogs, targeting 7 types of parasites in one chewable tablet. Based on label comparison of the number of parasite types covered in a chewable that targets ticks.
  • This flea and tick treatment is the first and only chewable for dogs that covers ticks, fleas, heartworm disease, New World screwworm larvae, and 3 intestinal worms that can be passed to humans — roundworms, hookworms and tapeworms. Based on label comparison of the number of parasite types covered in a chewable that targets ticks.
  • This tick and flea chewable begins to kill ticks (Ixodes ricinus) and fleas within 4 hours, so there can be one less thing to come between you and your pet.
  • TASTY & EASY TO GIVE: This FDA-approved parasite coverage comes in a flavored chewable tablet, with successful administration to 98% of dogs in a U.S. field study. [1] Elanco Animal Health. Data on file. REF-29606
  • PRESCRIPTION REQUIRED: Credelio Quattro / Credelio Quattro-CA1 is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.
  • Credelio Quattro protects dogs against ticks, fleas, heartworm disease, roundworms, hookworms, and tapeworms. Credelio Quattro-CA1 is conditionally approved for the treatment of New World screwworm larvae infestations in dogs pending a full demonstration of effectiveness.

Ingredients

Instructions

FAQ

Get 6-in-1 Parasite Protection

Introducing Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) for dogs, a prescription medication that protects your dog from common parasites. Unlike other chewables, Credellio Quattro protects against 6 types of parasites, including ticks, fleas, heartworm disease and three intestinal worms that can be passed to humans – 3 species of tapeworms, roundworms and hookworms.

Protection in a Tasty Chewable

Credelio Quattro combines convenience with flavor. A beef-flavored, once-monthly tablet that makes it easy to administer. Enjoy peace of mind knowing your dog’s protection is effective and easy to give.

The Power of Four

Credelio Quattro features four tried and true active ingredients designed to combat parasites effectively. With lotilaner, moxidectin, pyrantel and praziquantel, this advanced formula provides your pet with the broadest parasite protection of its kind based on label comparison of the number of parasite types covered.

Shown To Be Safe for Dogs and Puppies

Use Credelio Quattro to help protect your dog proactively before problems happen. This preventive treatment is shown to be safe for puppies as young as 8 weeks old and weighing at least 3.3 lbs.

About Credelio Quattro

Prescription only. Ask your veterinarian if Credelio Quattro is right for your dog.

Shop Credelio

Indications: Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm, and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater. Credelio Quattro is indicated for the prevention of Lyme disease infections as a direct result of killing black-legged ticks. Credelio Quattro-CA1 is conditionally approved for the treatment of infestations caused by New World screwworm (NWS) larvae in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.

Important Safety Information: Lotilaner, an ingredient in Credelio Quattro/Credelio Quattro-CA1, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, incoordination, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro/Credelio Quattro-CA1 administration as it is not effective against adult heartworms. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. 

Credelio Quattro-CA1 is conditionally approved by the FDA pending a full demonstration of effectiveness under application number 141-619. If you suspect that your dog is infested with NWS larvae, seek veterinary care immediately for treatment to include removal of larvae and appropriate wound care.

For complete safety information, please see the Credelio Quattro/Credelio Quattro-CA1 product label or ask your veterinarian.

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4.6
Rated 4.6 out of 5 stars
693 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

84% Positive

Ingredients

80% Positive

Long-Term Benefits

82% Positive

224 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
Verified Purchase
By Meredith on Apr 14, 2025

Delivery convenience

My dog is a service dog, and it would be medium difficult for me to give her all of these medications separately every month. It is really helpful to be able to

My dog is a service dog, and it would be medium difficult for me to give her all of these medications separately every month. It is really helpful to be able to do it once and be done with it. The picture is from the day we met. I just love it, so look at us!

Rated 3 out of 5 stars
Verified Purchase
By Melanie on Nov 8, 2025

CREDELIO QUATTRO

My dog was on heartguard+ until April 2025. Her heartworm tests were always negative. I switched her to this medication on May 15. I just came back from the vet

My dog was on heartguard+ until April 2025. Her heartworm tests were always negative. I switched her to this medication on May 15. I just came back from the vet yesterday withpositive heartworm results. Keira had been on this particular medication from May 15 to present. This medication obviously did not help prevent the heartworms, as I said, she is heartworm positive now. Being on a fixed income, we cannot afford to treat her for heartworms. I rated this three stars because she never had any fleas or ticks. This is way too expensive for merely treating fleas and ticks.. now I have to wonder how long I’m gonna get to enjoy my dog before the heartworms kill her.

Rated 1 out of 5 stars
Verified Purchase
By Patricia on Jan 3, 2026

poor delivery

Dogs do well on the prescription. However: Rcvd notification package was delivered. Camera did not show arrival. Checked at door in case camera malfunctioned

Dogs do well on the prescription. However: Rcvd notification package was delivered. Camera did not show arrival. Checked at door in case camera malfunctioned. Nope, no package. When checking website re: delivery; stated that pkg was left at front door. Walking dogs next morning, found package had been left on top of mailbox. Over $400.00 in dog meds left on the top of the mailbox on a dirt road at a rural address with properties more than an acre apart. Called Chewy to state dissatisfaction. C/S apologized. I'll find another supplier.

Rated 4 out of 5 stars
Verified Purchase
By Oliver on Jan 16, 2026

huge pill & very pricy - but it works!

this medication does a great job (we have not seen ANY fleas or ticks on our dog since starting it) BUT the pills are absolutely huge, like comically large. this

this medication does a great job (we have not seen ANY fleas or ticks on our dog since starting it) BUT the pills are absolutely huge, like comically large. this will be a real challenge if your dog has a hard time with pills. Chewy has by far the best price for this item especially with the chewy plus and autoship, but it is still very pricy, would be great to see this on sale more often, or see the price lowered.

Rated 4 out of 5 stars
Verified Purchase
By Carolyn on Feb 24, 2026

CREDELIO QUATTRO chewable tablets

I LOVE that this one monthly product prevents heartworm, treats and controls multiple varieties of roundworms, hookworm, and tapeworms. It kills adult fleas and

I LOVE that this one monthly product prevents heartworm, treats and controls multiple varieties of roundworms, hookworm, and tapeworms. It kills adult fleas and prevents future flea infestations. It also treats and prevents infestations of four types of dog ticks! WOW! It is a monthly tablet for all of those yucky bugs. I used to have to give all my dogs separate monthly medications including the very sticky liquid on their necks (you probably know what I’m talking about.) It is expensive BUT, if you add up all the products you’d need instead, it’s cost effective. Plus it’s only one thing to put on your calendar! I will say that the tablet for the 50-100 pound dogs is large. One of my dogs needs it covered in peanut butter first. Haha

Rated 1 out of 5 stars
Verified Purchase
By Luke on Jun 27, 2025

My dog died - only change was Credelio Quattro.

Andy, a 4 year, 9 month Golden Retriever had his annual vet visit on May 7th. Excellent health at 90 pounds. Changed from Frontline Plus and Heartguard to Credelio

Andy, a 4 year, 9 month Golden Retriever had his annual vet visit on May 7th. Excellent health at 90 pounds. Changed from Frontline Plus and Heartguard to Credelio Quattro on May 12th. A couple weeks later, he started losing his energy, vomited, and started to eat less. Changed his food and he ate more for a short time, but lost weight and energy. June 23rd he fell over. Loss of strength and coordination. Got him to the vet. Red blood cell count was extremely low. WBC count normal. No tick-borne disease. Kidney function normal. 80 pounds. Prescribed antibiotics and steroids. June 25th - Unable to walk. June 26th - Laid to rest. These are facts. Draw your own conclusions.

Rated 5 out of 5 stars
Verified Purchase
By Svetlana on Mar 7, 2025

Best protective combo in ONE pill!

I am so grateful that there is finally a ONE pill that covers all the bad parasites. It was recommended by my vet! My dog likes it a lot more than Trifexis (that

I am so grateful that there is finally a ONE pill that covers all the bad parasites. It was recommended by my vet! My dog likes it a lot more than Trifexis (that did not cover Ticks!). He ate it with food just fine, I did not even need to crush the pill or use Pill Pockets! Such a blessing! The only weird thing is that it appears to be 3 pills in "1" - but then I figured there is only one pill in the middle and two on sides are empty. Very happy overall!

Rated 3 out of 5 stars
Verified Purchase
By Brian on Nov 16, 2025

Horrible chemical smell my dog refuses to eat, no matter what i hide it in.

Works great I guess, my dog is still healthy and none of the problems it's supposed to ward off. Just get ready to have to jam the sizeable pill down your dog's

Works great I guess, my dog is still healthy and none of the problems it's supposed to ward off. Just get ready to have to jam the sizeable pill down your dog's throat. Mine fights me like I'm trying to kill him, and that's no laughing matter since he's 90 lbs of ornery fur, teeth, and claws. I hate this time of the month for both of us.

Rated 4 out of 5 stars
Verified Purchase
By Bailey on May 16, 2025

I think it works

As the weather is getting nicer, we've been taking our bernedoodle puppy on more hikes and I got this to make sure we wouldnt have any tick issues in the house

As the weather is getting nicer, we've been taking our bernedoodle puppy on more hikes and I got this to make sure we wouldnt have any tick issues in the house. After our second hike, I did find a dead tick on him when I brushed out his fluffy legs so I wouldn't say it totally repels ticks but at least kills them on impact

Rated 1 out of 5 stars
Verified Purchase
By Kathy on Dec 6, 2025

My dogs hate these pills

I have 3 dogs. 2 of them will eat virtually anything. Except Credelio Quattro. It's laughable that they are chews b/c my dogs will spit them out 100% of the time

I have 3 dogs. 2 of them will eat virtually anything. Except Credelio Quattro. It's laughable that they are chews b/c my dogs will spit them out 100% of the time even when hidden in cheese, peanut butter, pills pockets. There is no disguising the horrible taste and massive size of these things. They do work well but for the price and the major hassle of trying to get the dogs to take them, I'm not sure it's worth it.