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Credelio Quattro/Credelio Quattro-CA1 Chewable Tablets for Dogs, 25.1-50 lbs, 6 Chewables (6-mos. supply)

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About This Item

Details

  • Credelio Quattro/Credelio Quattro-CA1 helps bring peace of mind with the broadest parasite coverage of its kind available to dogs, targeting 7 types of parasites in one chewable tablet. Based on label comparison of the number of parasite types covered in a chewable that targets ticks.
  • This flea and tick treatment is the first and only chewable for dogs that covers ticks, fleas, heartworm disease, New World screwworm larvae, and 3 intestinal worms that can be passed to humans — roundworms, hookworms and tapeworms. Based on label comparison of the number of parasite types covered in a chewable that targets ticks.
  • This tick and flea chewable begins to kill ticks (Ixodes ricinus) and fleas within 4 hours, so there can be one less thing to come between you and your pet.
  • TASTY & EASY TO GIVE: This FDA-approved parasite coverage comes in a flavored chewable tablet, with successful administration to 98% of dogs in a U.S. field study. [1] Elanco Animal Health. Data on file. REF-29606
  • PRESCRIPTION REQUIRED: Credelio Quattro / Credelio Quattro-CA1 is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.
  • Credelio Quattro protects dogs against ticks, fleas, heartworm disease, roundworms, hookworms, and tapeworms. Credelio Quattro-CA1 is conditionally approved for the treatment of New World screwworm larvae infestations in dogs pending a full demonstration of effectiveness.

Ingredients

Instructions

FAQ

Get 6-in-1 Parasite Protection

Introducing Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) for dogs, a prescription medication that protects your dog from common parasites. Unlike other chewables, Credellio Quattro protects against 6 types of parasites, including ticks, fleas, heartworm disease and three intestinal worms that can be passed to humans – 3 species of tapeworms, roundworms and hookworms.

Protection in a Tasty Chewable

Credelio Quattro combines convenience with flavor. A beef-flavored, once-monthly tablet that makes it easy to administer. Enjoy peace of mind knowing your dog’s protection is effective and easy to give.

The Power of Four

Credelio Quattro features four tried and true active ingredients designed to combat parasites effectively. With lotilaner, moxidectin, pyrantel and praziquantel, this advanced formula provides your pet with the broadest parasite protection of its kind based on label comparison of the number of parasite types covered.

Shown To Be Safe for Dogs and Puppies

Use Credelio Quattro to help protect your dog proactively before problems happen. This preventive treatment is shown to be safe for puppies as young as 8 weeks old and weighing at least 3.3 lbs.

About Credelio Quattro

Prescription only. Ask your veterinarian if Credelio Quattro is right for your dog.

Shop Credelio

Indications: Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm, and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater. Credelio Quattro is indicated for the prevention of Lyme disease infections as a direct result of killing black-legged ticks. Credelio Quattro-CA1 is conditionally approved for the treatment of infestations caused by New World screwworm (NWS) larvae in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.

Important Safety Information: Lotilaner, an ingredient in Credelio Quattro/Credelio Quattro-CA1, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, incoordination, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro/Credelio Quattro-CA1 administration as it is not effective against adult heartworms. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. 

Credelio Quattro-CA1 is conditionally approved by the FDA pending a full demonstration of effectiveness under application number 141-619. If you suspect that your dog is infested with NWS larvae, seek veterinary care immediately for treatment to include removal of larvae and appropriate wound care.

For complete safety information, please see the Credelio Quattro/Credelio Quattro-CA1 product label or ask your veterinarian.

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Reviews
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4.6
Rated 4.6 out of 5 stars
523 Ratings
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Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

88% Positive

Ingredients

85% Positive

Long-Term Benefits

85% Positive

161 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
Verified Purchase
By Lori on May 18, 2026

Less itching

I have had my 2 English Setters on another flea and tick medication for years and it seemed that they were continuly scratching. My et recommened changing them

I have had my 2 English Setters on another flea and tick medication for years and it seemed that they were continuly scratching. My et recommened changing them to Credelio Quattro and it appears that they are not itching as much! Hope this continues to be the case as time goes on.

Rated 5 out of 5 stars
Verified Purchase
By Amanda on Mar 15, 2026

Great product

My vet has recommended credelio since my dog was a puppy. Its the top choice by my vet and when they made the credelio Quattro for both flea tick and heart worm

My vet has recommended credelio since my dog was a puppy. Its the top choice by my vet and when they made the credelio Quattro for both flea tick and heart worm protection I was already on both the meds just separately so I switched to this tablet now only have to give my dog one tablet but he still is protected from everything. He’s never once had fleas or ticks. He’s almost 6 years old now. So I stick with this brand.

Rated 5 out of 5 stars
Verified Purchase
By Steven on Sep 3, 2025

not for Daizie

I thought that chewy was absolutely wonderful in the handling of this purchase and when I called and explained that my dog would not take them and they worked with

I thought that chewy was absolutely wonderful in the handling of this purchase and when I called and explained that my dog would not take them and they worked with me and even returned some amount for us, and with that I was able to purchase another kind that we knew she would take. Thank You Chewy!

Rated 5 out of 5 stars
Verified Purchase
By Gregory on Mar 24, 2026

It works

Our picky pup doesn’t like the taste, but crush them and mix them into wet food and it’s a treat. No fleas, no ticks, happy campers here.

Our picky pup doesn’t like the taste, but crush them and mix them into wet food and it’s a treat. No fleas, no ticks, happy campers here.

Rated 5 out of 5 stars
Verified Purchase
By MARILYN on Apr 2, 2026

To be honest, I was swayed by a 30% off code.

This med really works well! At our cabin that is heavily timbered and has many ticks, even at the very end of 30 days it's still working. Dog only had 2 ticks

This med really works well! At our cabin that is heavily timbered and has many ticks, even at the very end of 30 days it's still working. Dog only had 2 ticks on her and they both had died before even being able to suck blood. As it prevents heartworm and other worms and kills fleas and ticks, it is replacing 2 pills a month and in that context it is really not unduly expensive.

Rated 4 out of 5 stars
Verified Purchase
By Brenda on May 17, 2026

Monthly preventative

I wanted a pull form of flea and tick with heartworm . I use seresto collars and wanted better protection for my dogs. We live near woods and ticks are an issue

I wanted a pull form of flea and tick with heartworm . I use seresto collars and wanted better protection for my dogs. We live near woods and ticks are an issue. I have only used a month and so far my dogs have less itching. It did upset Zoey’s stomach but I gave her a Pepcid AC and it settled her stomach. Next dose I will give her the Pepcid before hand.

Rated 1 out of 5 stars
By Alex on Feb 24, 2026

Dog hates this pill!

My dog who will eat pretty much anything despises this pill! He will pick it out of even the best foods. He vomited all his food up when I tried to pill him with

My dog who will eat pretty much anything despises this pill! He will pick it out of even the best foods. He vomited all his food up when I tried to pill him with this. Please make it taste better! Way too expensive for dog not to eat!

Rated 5 out of 5 stars
Verified Purchase
By Chandler on Jul 23, 2025

Easy to use

Got this instead of giving my dog two different meds each month. Works great and she seems to like it too.

Got this instead of giving my dog two different meds each month. Works great and she seems to like it too.

Rated 5 out of 5 stars
Verified Purchase
By Mindy on Jan 13, 2026

Easier to use

My dog hates taking any kind of pills or meds so just having to manage one of them is much easier. He has not had any issues at all so hopefully this will be his

My dog hates taking any kind of pills or meds so just having to manage one of them is much easier. He has not had any issues at all so hopefully this will be his go to monthly preventative. So glad they made one pill.

Rated 5 out of 5 stars
Verified Purchase
By Gregory on Dec 20, 2025

Works as advertised

My guy will NOT chew. I can't even hide them in is bowl. I wrap in hard salami after cutting in 4 pieces.

My guy will NOT chew. I can't even hide them in is bowl. I wrap in hard salami after cutting in 4 pieces.