Credelio Quattro Chewable Tablets for Dogs, 25.1-50 lbs, 6 Chewables (6-mos. supply)

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About This Item

Details

  • Credelio Quattro: The broadest1 parasite protection of its kind covering 6 types of parasites, including ticks, in one chewable tablet.
  • This monthly flea and tick treatment also protects against heartworm disease and three intestinal worms that can be passed to humans – roundworms, hookworms† and tapeworms † Uncinaria stenocephala
  • Easy-to-Give Chewable: This FDA-approved parasite protection comes in a flavored chewable tablet that is given once a month with food or within 30 minutes of a meal.
  • Prescription Only: Credelio Quattro is a prescription medication for puppies and dogs at least 8 weeks old and weighing at least 3.3 lbs.
  • 1Based on label comparison of the number of parasite types covered in an isoxazoline endectocide.

Ingredients

Instructions

FAQ

Get 6-in-1 Parasite Protection

Introducing Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) for dogs, a prescription medication that protects your dog from common parasites. Unlike other chewables, Credellio Quattro protects against 6 types of parasites, including ticks, fleas, heartworm disease and three intestinal worms that can be passed to humans – 3 species of tapeworms, roundworms and hookworms.

Protection in a Tasty Chewable

Credelio Quattro combines convenience with flavor. A beef-flavored, once-monthly tablet that makes it easy to administer. Enjoy peace of mind knowing your dog’s protection is effective and easy to give.

The Power of Four

Credelio Quattro features four tried and true active ingredients designed to combat parasites effectively. With lotilaner, moxidectin, pyrantel and praziquantel, this advanced formula provides your pet with the broadest parasite protection of its kind based on label comparison of the number of parasite types covered.

Shown To Be Safe for Dogs and Puppies

Use Credelio Quattro to help protect your dog proactively before problems happen. This preventive treatment is shown to be safe for puppies as young as 8 weeks old and weighing at least 3.3 lbs.

About Credelio Quattro

Prescription only. Ask your veterinarian if Credelio Quattro is right for your dog.

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Indications

Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm, and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.

Important Safety Information

Lotilaner, an ingredient in Credelio Quattro, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, ataxia, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro administration as it is not effective against adult D. immitis. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. For complete safety information, please see the Credelio Quattro product label or ask your veterinarian.

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Reviews
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4.6
Rated 4.6 out of 5 stars
329 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

88% Positive

Ingredients

84% Positive

Long-Term Benefits

85% Positive

90 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By MARILYN on Apr 2, 2026

To be honest, I was swayed by a 30% off code.

This med really works well! At our cabin that is heavily timbered and has many ticks, even at the very end of 30 days it's still working. Dog only had 2 ticks

This med really works well! At our cabin that is heavily timbered and has many ticks, even at the very end of 30 days it's still working. Dog only had 2 ticks on her and they both had died before even being able to suck blood. As it prevents heartworm and other worms and kills fleas and ticks, it is replacing 2 pills a month and in that context it is really not unduly expensive.

Rated 5 out of 5 stars
By Amanda on Mar 15, 2026

Great product

My vet has recommended credelio since my dog was a puppy. Its the top choice by my vet and when they made the credelio Quattro for both flea tick and heart worm

My vet has recommended credelio since my dog was a puppy. Its the top choice by my vet and when they made the credelio Quattro for both flea tick and heart worm protection I was already on both the meds just separately so I switched to this tablet now only have to give my dog one tablet but he still is protected from everything. He’s never once had fleas or ticks. He’s almost 6 years old now. So I stick with this brand.

Rated 5 out of 5 stars
By Montgomerie on Mar 11, 2026

No Allergy Issues for my Dog

My dog has food allergies and we had been using Nex-Guard, which was giving him digestive issues after administration. With Credelio Quattro our dog had no digestion

My dog has food allergies and we had been using Nex-Guard, which was giving him digestive issues after administration. With Credelio Quattro our dog had no digestion issues like we anticipated. We will be using this moving forward!

Rated 1 out of 5 stars
By Jennifer on Mar 12, 2026

Shipping address was somehow changed

I had an auto ship that went out March 4. It went to my old address however I just got in and looked and the auto ship is set to go to my new address soI’m not

I had an auto ship that went out March 4. It went to my old address however I just got in and looked and the auto ship is set to go to my new address soI’m not sure why my old address is the one they sent to.

Rated 1 out of 5 stars
By Alex on Feb 24, 2026

Dog hates this pill!

My dog who will eat pretty much anything despises this pill! He will pick it out of even the best foods. He vomited all his food up when I tried to pill him with

My dog who will eat pretty much anything despises this pill! He will pick it out of even the best foods. He vomited all his food up when I tried to pill him with this. Please make it taste better! Way too expensive for dog not to eat!

Rated 5 out of 5 stars
By Gregory on Mar 24, 2026

It works

Our picky pup doesn’t like the taste, but crush them and mix them into wet food and it’s a treat. No fleas, no ticks, happy campers here.

Our picky pup doesn’t like the taste, but crush them and mix them into wet food and it’s a treat. No fleas, no ticks, happy campers here.

Rated 5 out of 5 stars
By Jessica on Apr 3, 2026

One pill, so easy!

My dog ate these like they were a treat, and it was easy to remember one pill instead of 2 different medications a month.

My dog ate these like they were a treat, and it was easy to remember one pill instead of 2 different medications a month.

Rated 2 out of 5 stars
By Cindy on Mar 24, 2026

all in one protection

Sox did not do well with the first dose-lethargic, diarrhea, over all just not feeling well for a few days. I will try one more time.

Sox did not do well with the first dose-lethargic, diarrhea, over all just not feeling well for a few days. I will try one more time.

Rated 5 out of 5 stars
By Valentina on Feb 13, 2026

Great service, very convenient

The pharmacists are great and easy to work with. I used to wait until last minute to pick up the pill at the vet. This service works way better for my busy schedule

The pharmacists are great and easy to work with. I used to wait until last minute to pick up the pill at the vet. This service works way better for my busy schedule and i can save some money too!:)

Rated 4 out of 5 stars
By Madonna on Dec 29, 2025

Possible Reaction to this

We have 2 Two year old Shibas and the smaller one had a horrible allergic reaction shortly after switching to this med. It took months for him to look like normal

We have 2 Two year old Shibas and the smaller one had a horrible allergic reaction shortly after switching to this med. It took months for him to look like normal again. Itching, turned black around eyes and snout. Scratched hair off legs and his behind. Vet swears it couldn't be the med, but Im not trying it again. Went back to heart guard and NEXT GUARD.