Apoquel (oclacitinib) TABLETS for Dogs, 3.6-mg, 30 tablets
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- #1 Prescribed Oral Medicine for Allergy Relief in Dogs: Provides fast, effective allergy relief for dogs 12 months and older. Can be used short-term or long-term.
- Stops Allergic Itch at the Source: Not a steroid, antihistamine, or cyclosporine (a drug that reduces immune system activity). Apoquel works differently by blocking allergic itch at the source.
- Fast-Acting Relief: Starts working within 4 hours and controls allergic itch within 24 hours to help stop scratching, licking, and chewing.
- Can Be Used with Many Other Medications: Compatible with nonsteroidal anti-inflammatory drugs (NSAIDs), vaccines (such as rabies), and allergen-specific immunotherapy (allergy shots or drops). Not evaluated with other systemic immunosuppressants.
- Available in Three Strengths 3.6 mg, 5.4 mg, and 16 mg tablets based on your dog’s weight. Give once daily with or without food.
- Trusted by Veterinarians: Prescribed to over 14 million dogs and counting.
Ingredients
Instructions
FAQ
Fast-Acting Allergic Itch Relief For Your Dog
Apoquel is a revolutionary oral medicine for dogs with allergic itch. Unlike other medicines, it stops allergic itch at the source and provides fast-acting itch relief in as little as 4 hours.[1,2,*]
#1 Prescribed Oral Product for Allergic Itch [3]
Apoquel has been prescribed for over 17 million dogs and counting.[4] It is #1 in pet owner and vet satisfaction for oral medications for allergic dermatitis in dogs.[5,6]
Approved for Short-Term and Long-Term Use
Apoquel can be used short-term or for long-term maintenance therapy in dogs 12 months of age and older.[7,8,*] It’s available in a tasty, treat-like chewable for dogs that are difficult to pill or in the original tablet formulation and comes in three strengths for dogs of all sizes. Talk to your veterinarian about which is right for your dog.
Easy-to-Give Chewable Formulation Available
Apoquel Chewable (oclacitinib chewable tablet) is a tasty, treat-like chewable for dogs that are difficult to pill. It’s the first and only chewable treatment for the relief of allergic itch in dogs, built on the proven legacy of Apoquel Tablet.
Control Allergic Itch & Earn Rewards From Zoetis
Your Apoquel purchase may be eligible for Petcare Rewards points. Redeem your points for Rewards toward future veterinary care & more!
Important Safety Information
Do not use Apoquel or Apoquel Chewable in dogs less than 12 months of age or those with serious infections. Apoquel and Apoquel Chewable may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post approval. Apoquel and Apoquel Chewable have not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel and Apoquel Chewable have been used safely with many common medications including parasiticides, antibiotics and vaccines. See full Prescribing Information at ApoquelTabletAndChewablePI.com.
*Based on a model study for flea allergic dermatitis.
REFERENCES
1. Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Journal of Veterinary Pharmacology and Therapeutics. 2014;37(4):317-324. doi:10.1111/vp.12101.
2. Gadeyne C, Little P, King VL, Edwards N, Davis K, Stegemann MR. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol. 2014;25(6):512-518,e86. doi:10.1111/vde.12166.
3. Kynetec - PetTrak, US Pruritus Factored National. MAT Canine Pruritus, Total Unique Patients on Apoquel. Dec. 2023, Zoetis Inc.
4. ZMR: Kynetec GAH- 284 Cytopoint & Apoquel Pets Since Launch, January 2014 to December 2025
5. Data on file, Apoquel/Cytopoint Vet Tracker Wave 18, 2024, Zoetis Inc.
6. ZMR: Apoquel, Apoquel Chewable & Cytopoint Dog Owner A&U Tracking Study: Wave 13 November 26, 2024
7. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479- e114. doi: 10.1111/vde.12047.
8. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi: 10.1111/vde.12194.
APC-00203R1
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Customers Mention
Ease of Use
Effectiveness
Ingredients
Long-Term Benefits
5941 Customer Reviews
Highly recommended for allergy sensitive dogs
I rescued a small chihuahua that did not have any hair, skin smelled even after baths, and she scratched so bad even in her sleep. The vet wanted to do blood work
I rescued a small chihuahua that did not have any hair, skin smelled even after baths, and she scratched so bad even in her sleep. The vet wanted to do blood work and prescribe other medicines when I knew it was allergies and her nutritional intake. I started her on a high protein grain free diet and this medicine and she immediately improved. She stopped scratching, her hair grew back, and she doesnt have that horrible smell to her skin. Highly recommend using this product for allergy sensitive pets.
Miracle worker!
I was at my wits end with my chiweenie’s allergies. One of her ears was raw and bloody from her constant scratching. We tried cones but her ears would not heal
I was at my wits end with my chiweenie’s allergies. One of her ears was raw and bloody from her constant scratching. We tried cones but her ears would not heal. The vet gave me ointment to put on her ears but she would freak out if I touched it or tried to spray anything on it. She was miserable and we were miserable for her. I started researching stuff myself and read about Apoquel and asked the vet for a prescription. That was the absolute best decision I ever made! By that night, she wasn’t scratching as much. Within a week her ear was looking great. I was able to slowly taper her down on the dosage. She is now at 1/2 pill every other day. I’d like to get her down more eventually. I wait a month to give each dose a chance and then go down a bit more the next one to see if she tolerates it. I know the medication is pricey but it is so worth it! She’s a happy dog again!
Apoquel and Purina HA have been fantastic in managing Dakota’s allergies over the last few years but we’ll be discontinuing year-round use. He’s getting up there
Apoquel and Purina HA have been fantastic in managing Dakota’s allergies over the last few years but we’ll be discontinuing year-round use. He’s getting up there in age and the last thing I want is to unintentionally give him a death sentence by suppressing his immune system when he needs it most. Chewy was fast and efficient at delivering his meds but their price is still extremely cost prohibitive. This shouldn’t be cheaper at other online pharmacies like Bandana when you’re the #1 online pet retailer in America.
Gave my dog anxiety
I rate this 3 stars because it significantly alleviated my German Shepherd's allergies. However, he developed REALLY bad anxiety. He began hiding in the closet,
I rate this 3 stars because it significantly alleviated my German Shepherd's allergies. However, he developed REALLY bad anxiety. He began hiding in the closet, retreating to the basement to lie down, and just behaving very oddly. We tried EVERYTHING, and eventually, my vet mentioned that she had heard of this pill causing such side effects. We discontinued it, and he immediately returned to his normal self unfortunately, the itching resumed, so we had to reintroduce it. Bam! Anxiety returned, hiding in closets, and so on. I didn't want him on this medication any longer, so we changed his diet, and now the allergies are gone. His diet consists of Victor sensitive skin and stomach, the fish one, and I make a food topper of salmon and beef liver that I mix myself. Allergies are gone he's allergic to chicken, beef, and turkey. each time we introduced this pill, anxiety was heightened
Night and day
Without these pills I dont think my Benjamin would survive. I just need them to be more affordable. 3.20 per pill everyday is a lot to pay on top of everything
Without these pills I dont think my Benjamin would survive. I just need them to be more affordable. 3.20 per pill everyday is a lot to pay on top of everything else he needs. Im single and money is tight.
Expensive
It does work. All other meds do not. When I started buying this for Mario, the cost was 40.00 a month. Now it is 93.00 I understand everything has gone up. They
It does work. All other meds do not. When I started buying this for Mario, the cost was 40.00 a month. Now it is 93.00 I understand everything has gone up. They do not make a generic brand. Come on CHEWY make an alternative that cost less please and thank you
The last medication my elderly dog will ever take
My 14 y/o Olde English Bulldogge, Zilla, has struggled with skin/stomach/eye/ear/paw issues for a majority of her adult life. After 10s of thousands of dollars spent
My 14 y/o Olde English Bulldogge, Zilla, has struggled with skin/stomach/eye/ear/paw issues for a majority of her adult life. After 10s of thousands of dollars spent on pet insurance, vet bills, and medications, it finally feels like I've found a real solution. It's not a cheap solution, but it's cheaper and actually works without going through the yo-yoing of putting her on antibiotics/steroids when things went from bad to worse and then running out and having her go back to being miserable. Apoquel has COMPLETELY resolved ALL of Zilla's skin issues. All of her neck and belly hair has grown back, her ears are no longer swollen/smelly/eminent infection (she can hear again!), and the space between the pads of her paws look like they did when she was a puppy. No more sneezing and her eyes are less red and irritated. The only side effect I've seen, other than all the positive ones, is dry mouth. I don't usually leave reviews but felt driven to share given the life changing effect it's had for my old girl. It's a no-brainer for me despite it's price--given her age and wanting to make the absolute most of her golden years.
How well it worked for my Dollie
Another vet at the same office saw Dollie and told me it could be her food , and then he told me why she was scratching all the time, I was so worried for Dollie
Another vet at the same office saw Dollie and told me it could be her food , and then he told me why she was scratching all the time, I was so worried for Dollie so he wrote dawn Dog food that didn't have grapes in it because that was what I found out the food I was giving her had grane in it ,so I switched to grane free purrina. pro-plan , now she's doing great!!!!
Vet recommended
My dog has had terrible allergies with her feet and they were bleeding and scabby and just awful! Her poor belly was beet red and scabby and I’ve had her to vet
My dog has had terrible allergies with her feet and they were bleeding and scabby and just awful! Her poor belly was beet red and scabby and I’ve had her to vet so many times I’m quite overwhelmed. They’ve always said it was food but this vet believes it’s environmental. I’ve had her on Apoquel forever and don’t see that it’s helpful but vet changed her to non-chewable. I’ve got to put boots on her when we go outside but they’re too big so I will let vet look at that. She has been on antibiotics and a spray for staph and is wearing a cone. Vet said to give her 9 Benadryl per day as well. Her and I are in this together. My third pittie and she was a rescue. I’m thankful I am able to take care of her with so many issues!!
Be warned
Apoquel affects the immune system and makes a dog more susceptible. There are side effects that people don't mention and that is ear infections and skin infections
Apoquel affects the immune system and makes a dog more susceptible. There are side effects that people don't mention and that is ear infections and skin infections "hotspots". I just had a conversation with the chewy representative today while ordering another bottle of apoquel. He noted that I'm on my 30th purchase and that I should get on the frequent flyer plan basically. I've got three German shepherds and they have all acquired the same allergies of extreme itching. Two of the three of my shepherds regularly experience hotspots and extreme ear infections during this medication. I have my own little trial lab. I'm currently considering the alternative to apoquel in hopes that I can cut down on the side effects that I then have to spend more money on for those occurrences. One of my dogs before all three got the same allergies was never given apoquel by one of my good friends that was my vet. He retired and I had to use another vet. He knew about how apoquel affected the dogs immune system and I can't remember exactly what else but it makes your dog weaker and you need to check its blood if you're on it regularly. I have the three dogs that require a full prescription per month and its the cost of a car so I'm going into the diet giving the farmer's dog dog food a try. It'll be pricey but no reason my dog should be popping pills everyday of their lives. But I'm glad apoquel is here because they need it every 24 hours. I could tell the time by their scratching