Apoquel (oclacitinib) Tablets for Dogs, 16-mg, 1 tablet

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About This Item

Details

  • #1 Prescribed Oral Medicine for Allergy Relief in Dogs: Provides fast, effective allergy relief for dogs 12 months and older. Can be used short-term or long-term.
  • Stops Allergic Itch at the Source: Not a steroid, antihistamine, or cyclosporine (a drug that reduces immune system activity). Apoquel works differently by blocking allergic itch at the source.
  • Fast-Acting Relief: Starts working within 4 hours and controls allergic itch within 24 hours to help stop scratching, licking, and chewing.
  • Can Be Used with Many Other Medications: Compatible with nonsteroidal anti-inflammatory drugs (NSAIDs), vaccines (such as rabies), and allergen-specific immunotherapy (allergy shots or drops). Not evaluated with other systemic immunosuppressants.
  • Available in Three Strengths 3.6 mg, 5.4 mg, and 16 mg tablets based on your dog’s weight. Give once daily with or without food.
  • Trusted by Veterinarians: Prescribed to over 14 million dogs and counting.

Ingredients

Instructions

FAQ

Learn More About Apoquel From Our Team of Experts

Fast-Acting Allergic Itch Relief For Your Dog

Apoquel Tablet is the #1 prescribed oral medication for allergic itch in dogs [1]. Unlike other allergic itch treatments, such as steroids, antihistamines, and at-home remedies, Apoquel works at the underlying cause of the itch to provide fast relief.

Apoquel Stops Allergic Itch Right at the Source

If your dog is scratching, licking or chewing like crazy, you want to provide relief that starts acting quickly. Apoquel Chewable effectively controls allergic itch within 24 hours [2].

Approved for Short-Term and Long-Term Use

Apoquel Chewable can be used for long-term maintenance or short-term therapy [3,4].

Prescribed for Over 15 Million Dogs  and Counting[5]

Apoquel Tablets are #1 in pet owner and vet satisfaction for oral medications 
for allergic itch in dogs [*6,7].

About Apoquel

Apoquel is a revolutionary oral medication for dogs with allergic itch. It works differently than other medications by going right to the source to stop the underlying cause of itch in dogs with skin allergies [6]. Apoquel is offered as either a tablet or chewable formulation with a veterinarian's prescription. Talk to your vet about what's best for your dog.

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Important Safety Information

See full Prescribing Information. Do not use Apoquel Chewable in dogs less than 12 months of age or those with serious infections. Apoquel Chewable may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions.  New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval.  Apoquel Chewable has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel Chewable has been used safely with many common medications including parasiticides, antibiotics and vaccines.

INDICATIONS: Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

*Vets, n=250; pet owners, n=491.

References:

[1] Visser M, Walsh K, King V, Sture G, Caneva L. Acceptance of oclacitinib maleate (Apoquel) chewable tablets in client-owned dogs with allergic and atopic dermatitis. BMC veterinary research. 2022;18(1):103. doi:10.1186/s12917-022-03210-x

[2] Data on file: Study Report A161C-US-21-C02, Zoetis Inc., 2022.

[3] Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479- e114. doi: 10.1111/vde.12047.

[4] Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi: 10.1111/vde.12194.

[5] Data on file, ZMR: Adelphi/PROVE: Pet Owner Preferences Chewable Vs. Conventional Canine Pruritus, Zoetis Services LLC, March 2023. N= 262 pet owners.

[6] Data on file, APOQUEL/CYTOPOINT Vet Tracker Wave 17, 2022, Zoetis Inc.

[7] Data on file, APOQUEL/CYTOPOINT Pet Owner Tracker Wave 11, 2022, Zoetis Inc.

[8] Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL(®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Journal of Veterinary Pharmacology and Therapeutics. 2014;37(4):317-324. doi:10.1111/vp.12101.

APC-00203

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4.7
Rated 4.7 out of 5 stars
14726 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

85% Positive

Ingredients

84% Positive

Long-Term Benefits

84% Positive

5813 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Raul on Mar 20, 2026

It works

Best in the business and that’s why it cost so much. However this is probably the less expensive place where you can buy it. One those thing we wait for a generic

Best in the business and that’s why it cost so much. However this is probably the less expensive place where you can buy it. One those thing we wait for a generic however apoquel is going to make their money on this pill. My dog would look like a rag doll if it wasn’t for this medicine. Antihistamine don’t work, well they work for allergies reactions but not for long term effects.

Rated 5 out of 5 stars
By albert on Apr 2, 2026

It works!!!

My poor boy is allergic to alot of stuff tried all the snake oil remedies that were a waste of time and money, this is the only thing that works, stopped itching

My poor boy is allergic to alot of stuff tried all the snake oil remedies that were a waste of time and money, this is the only thing that works, stopped itching and hives and now he’s more energetic and putting on weight and doesn’t look malnourished. He’s an American bully and supposed to be bulky not a twig.

Rated 5 out of 5 stars
By Elizabeth on Mar 17, 2026

She stopped her constant licking

I bought this because Miley was constantly licking her paws at night (her allergies )and this would keep me up all night since she sleeps in the room with me. What

I bought this because Miley was constantly licking her paws at night (her allergies )and this would keep me up all night since she sleeps in the room with me. What I appreciated more was that the person I spoke with at chewy.com suggested that I give her the medication at night thus letting both of us sleep because Miley is no longer constantly chewing and licking her paws.

Rated 5 out of 5 stars
By Laura on Mar 28, 2026

Fast results

Thrilled how comfortable my dog is He has terrible Seasonal allergies he likes to swim in our pond and roll in the grass previously this was a disaster red itchy

Thrilled how comfortable my dog is He has terrible Seasonal allergies he likes to swim in our pond and roll in the grass previously this was a disaster red itchy skin everywhere he was miserable now he can run and play with no allergy symptoms what a relief

Rated 1 out of 5 stars
By Sydney on Mar 6, 2026

Disappointed product

If this type of medication is recommend from your vet. Do not get medication. My Pet, Maggie has been on this medication for almost 5 years. Veterinary clinic I

If this type of medication is recommend from your vet. Do not get medication. My Pet, Maggie has been on this medication for almost 5 years. Veterinary clinic I went to Only wanted to increase the dosage but it has not improved. I have read the side effects and she has all of them! This just breaks my heart because I trusted the VET’s that they would take care of her needs but really leaving her to become more miserable.

Rated 5 out of 5 stars
By Barbara on Mar 6, 2026

Speedy Delivery!!

After a harrowing experience with our vet (previous vet now), Chewy worked tirelessly with me to get Piper’s Rxs confirmed, approved and delivered! They expedited

After a harrowing experience with our vet (previous vet now), Chewy worked tirelessly with me to get Piper’s Rxs confirmed, approved and delivered! They expedited them for her since she had been without them for over a week. Her meds arrived early! We really appreciate the care and concern shown for her health and comfort!!

Rated 2 out of 5 stars
By tracy on Feb 15, 2026

Wrong quantity of medication

I was extremely disappointed to receive only half of the quantity of medication ordered. When I contacted customer service I was told that the remaining quantity

I was extremely disappointed to receive only half of the quantity of medication ordered. When I contacted customer service I was told that the remaining quantity of the prescription was for that amount of medication. When they were in contact with our vet, they could have easily gotten approval for the correct amount. This medication is much more expensive in the smaller quantity.

Rated 3 out of 5 stars
By Lauren on Feb 22, 2026

Gave my dog anxiety

I rate this 3 stars because it significantly alleviated my German Shepherd's allergies. However, he developed REALLY bad anxiety. He began hiding in the closet,

I rate this 3 stars because it significantly alleviated my German Shepherd's allergies. However, he developed REALLY bad anxiety. He began hiding in the closet, retreating to the basement to lie down, and just behaving very oddly. We tried EVERYTHING, and eventually, my vet mentioned that she had heard of this pill causing such side effects. We discontinued it, and he immediately returned to his normal self unfortunately, the itching resumed, so we had to reintroduce it. Bam! Anxiety returned, hiding in closets, and so on. I didn't want him on this medication any longer, so we changed his diet, and now the allergies are gone. His diet consists of Victor sensitive skin and stomach, the fish one, and I make a food topper of salmon and beef liver that I mix myself. Allergies are gone he's allergic to chicken, beef, and turkey. each time we introduced this pill, anxiety was heightened

Rated 1 out of 5 stars
By Misty on Feb 6, 2026

Ridiculously slow delivery and then delivered to wrong place

This delivery took twice the amount of time than it ever has before, even with needing auth by the vet. No bad weather. The worst part was that when I finally did

This delivery took twice the amount of time than it ever has before, even with needing auth by the vet. No bad weather. The worst part was that when I finally did receive my boys meds, the driver put it at a random side of my house that was clearly not the front door where I have a doorbell camera. Packages get stolen all the time in my neighborhood. I will be looking for another place to purchase prescription medications that are over $3.59 a pill.

Rated 1 out of 5 stars
By Colleen on Mar 10, 2026

Mix ups with the order

After ordering my dogs rx, got an email saying Chewy was waiting for my vet's approval. When I originally ordered I told the rep the vet on file needed changed

After ordering my dogs rx, got an email saying Chewy was waiting for my vet's approval. When I originally ordered I told the rep the vet on file needed changed. He assured me it was done and new vet added. Chewy attempted to get a reply from previous not new vet. This caused delays and confusion on this order. It eventually got worked out but the delay caused my dog to go too long with the needed rx. And, it wasn't as if I ordered the rx and had no back ups. I had several days and expected when that ran out the new rx would have arrived.