Apoquel (oclacitinib chewable tablet) Chewable for Dogs, 16-mg, 120 tablets

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About This Item

Details

  • #1 Prescribed Oral Medicine for Allergy Relief in Dogs: Fast, effective allergy relief for dogs 12 months and older. Suitable for short-term or long-term use.
  • Stops Allergic Itch at the Source: Not a steroid, antihistamine, or cyclosporine (a drug that reduces immune system activity). Works differently to block allergic itch where it starts.
  • Fast-Acting Relief: Begins working within 4 hours and controls allergic itch within 24 hours to help stop scratching and chewing fast.
  • Can Be Used with Many Other Medications: Compatible with nonsteroidal anti-inflammatory drugs (NSAIDs), vaccines (such as rabies), and allergen-specific immunotherapy. Not evaluated with other systemic immunosuppressants.
  • Available in Three Strengths: 3.6 mg, 5.4 mg, and 16 mg pork-liver flavored chewable tablets. Give once daily with or without food.

Ingredients

Instructions

FAQ

Learn More About Apoquel From Our Team of Experts

The Welcome Taste of Fast-Acting  Allergic Itch Relief

The first and only chewable treatment for the control of allergic itch in dogs. Apoquel Chewable is a tasty pork liver-flavored chewable. A recent study showed that Apoquel Chewable was accepted by over 90% of dogs. [1]

Apoquel Stops Allergic Itch Right at the Source

If your dog is scratching, licking or chewing like crazy, you want to provide relief that starts acting quickly. Apoquel Chewable effectively controls allergic itch within 24 hours [2].

Approved for Short-Term and Long-Term Use

Apoquel Chewable can be used for long-term maintenance or short-term therapy [3,4].
9 millimeter equals 3.6 milligrams, 10 millimeter equals 5.4 milligrams, and 15 millimeter equals 16 milligrams

Struggling with Giving Pills?

A survey showed 70% of pet parents preferred a chewable tablet* and 65% of pet parents struggle with conventional tablet-based therapies [5]. With a treat-like formulation, Apoquel Chewable may simplify dosing and help eliminate the stress from giving pills. Talk to your vet to see if Apoquel Chewable could be right for your dog. It's easy to give and comes in 3 strengths to suit your dog’s body weight.

*Responses based on owner review of Apoquel Tablet and Apoquel Chewable product profiles in a survey

About Apoquel

Apoquel is a revolutionary oral medication for dogs with allergic itch. It works differently than other medications by going right to the source to stop the underlying cause of itch in dogs with skin allergies [6]. Apoquel is offered as either a tablet or chewable formulation with a veterinarian's prescription. Talk to your vet about what's best for your dog.

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Important Safety Information

See full Prescribing Information. Do not use Apoquel Chewable in dogs less than 12 months of age or those with serious infections. Apoquel Chewable may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions.  New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval.  Apoquel Chewable has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel Chewable has been used safely with many common medications including parasiticides, antibiotics and vaccines.

INDICATIONS: Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

References:

[1] Visser M, Walsh K, King V, Sture G, Caneva L. Acceptance of oclacitinib maleate (Apoquel) chewable tablets in client-owned dogs with allergic and atopic dermatitis. BMC veterinary research. 2022;18(1):103. doi:10.1186/s12917-022-03210-x 

[2] Data on file: Study Report A161C-US-21-C02, Zoetis Inc., 2022.

[3] Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479- e114. doi: 10.1111/vde.12047.

[4] Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi: 10.1111/vde.12194.

[5] Data on file, ZMR: Adelphi/PROVE: Pet Owner Preferences Chewable Vs. Conventional Canine Pruritus, Zoetis Services LLC, March 2023. N= 262 pet owners.

[6] Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL(®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Journal of Veterinary Pharmacology and Therapeutics. 2014;37(4):317-324. doi:10.1111/vp.12101. 

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4.7
Rated 4.7 out of 5 stars
10264 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

83% Positive

Effectiveness

82% Positive

Ingredients

82% Positive

Long-Term Benefits

82% Positive

3590 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By Tara on Apr 3, 2026

Fast and Effective!

Lily had red, raised. inflamed irritations all over her belly, back legs, spread spreading into her chest area. I knew that it had to be to an allergic reaction

Lily had red, raised. inflamed irritations all over her belly, back legs, spread spreading into her chest area. I knew that it had to be to an allergic reaction to something in the yard. Within two days of being on this medication, I saw an improvement. Within a week, my girl was back to jumping, wagging her tail, and doing less slick and scratching.

Rated 4 out of 5 stars
By KAREN on Mar 29, 2026

The medicine is good

The actual medicine is good for my dog but she isn't crazy about the taste and seems a bit hard for a chewable. I have tried cutting it up and surrounding it with

The actual medicine is good for my dog but she isn't crazy about the taste and seems a bit hard for a chewable. I have tried cutting it up and surrounding it with peanut butter or many other tricks but she will still find it and spit it out most of the time. But that is my dog. The medicine makes her less itchy and sneezy - so that is why she gets it.

Rated 5 out of 5 stars
By Austin on Mar 7, 2026

Significant Improvement

My dog would lick herself incessantly. It was guttural, annoying, frustrating, and I didn’t know what to do. Since we started her on these (I got the 16mg), she

My dog would lick herself incessantly. It was guttural, annoying, frustrating, and I didn’t know what to do. Since we started her on these (I got the 16mg), she has stopped licking her “sensitive regions” and paws almost completely. There’s still some licking here and there, but it’s nowhere near as intense and doesn’t last very long. I just got 30 to start out but I’m signing up for the subscription to save some money now that I know it works. Definitely recommend you at least try it instead of spending hundreds a month on allergy shots.

Rated 5 out of 5 stars
By Patti on Mar 23, 2026

Swiftness of relief

My poor dog was covered in welts and her armpits and feet were raw and bleeding. Her legs were so bad they were gooey with pus. The day after her first pill, the

My poor dog was covered in welts and her armpits and feet were raw and bleeding. Her legs were so bad they were gooey with pus. The day after her first pill, the smaller welts were all gone and she had quit scratching and chewing. I'd tried benadryl, changed her food to no chicken and nothing worked except this miracle pill. It is dang expensive but wow it works!

Rated 3 out of 5 stars
By Jaimie on Apr 2, 2026

Not that great

We had been using Benadryl for the last year for our dogs itchy skin. The vet said to try Apoquel, so we did. It has been no different than the Benadryl for treating

We had been using Benadryl for the last year for our dogs itchy skin. The vet said to try Apoquel, so we did. It has been no different than the Benadryl for treating our girls symptoms. Let's do the math - Apoquel $90 a month, or Benadryl $6 a month = we will stick with the Benadryl!

Rated 5 out of 5 stars
By ISABEL on Mar 11, 2026

A big help for my dog’s allergies!!

When spring starts my dog starts itching like crazy. His ears turn red and irritated, skin gets rashes and he is uncomfortable. Apoquel works and makes him comfortable

When spring starts my dog starts itching like crazy. His ears turn red and irritated, skin gets rashes and he is uncomfortable. Apoquel works and makes him comfortable. He takes the chewable tablet without hesitation (i am sure he likes the taste), so this is definitely a great thing that a chewable tablet is available.

Rated 2 out of 5 stars
By Maria on Feb 9, 2026

LAte delivery, medication exposed to freezing temerature-is is still usable?

delivery was almost 2 weeks late, email notices did not match delivery date at all. I worry that the product has been exposed to freezing tempertures by dropping

delivery was almost 2 weeks late, email notices did not match delivery date at all. I worry that the product has been exposed to freezing tempertures by dropping package at an unexpected location,( below my mailbox on the street) and leaving it there exposed to the elements as well as theft. Packege was not meant for mailbox, it was a lot bigger, deliveries normally bring it at least up to the gate, if not front door. Another worry is that medication in the package has been exposed to freezing temperatures during the 10 days transit, in storage/warehouse. I am thinking about returning product and get it replaced due to delivery hardships that might have compromised the product's usability.

Rated 1 out of 5 stars
By David on Feb 4, 2026

Prescription dropped off where dog could get it!

The carrier left a box of prescription Apoquel pills on my front doorstep. It contained 60 tablets. My 1 year old dog, Star, a 100 pound Anatolian Shepherd, took

The carrier left a box of prescription Apoquel pills on my front doorstep. It contained 60 tablets. My 1 year old dog, Star, a 100 pound Anatolian Shepherd, took the box and ripped it open. She ingested all 60 pills. I was horrified. I rushed her to the emergency vet and they induced vomiting and gave her activated charcoal and put her on an IV with lipids. I spent the entire night with her. Thank God she pulled through but we don’t know what long term effects of the overdose will have on her liver, kidneys and cardiovascular system. My bill was almost $5,000. There must be a law that packages with prescription drugs be labeled so a carrier is required to either have the package signed or placed in a secure location to ensure that no animal or child can have access to it. I have just spent the last 48 hours on an emotional roller coaster of grief wondering if my best friend was going to live or die. This should never have happened and I pray no one else has to go through what our family just did.

Rated 5 out of 5 stars
By Bonnie on Feb 17, 2026

Apoquel

These are amazing pills, our dog has allergies and without these she will chew her feet until they are bloody and she can’t walk on them. I only wish I knew what

These are amazing pills, our dog has allergies and without these she will chew her feet until they are bloody and she can’t walk on them. I only wish I knew what was causing the allergies we’ve tried a lot of different foods like the vet suggested but nothing seems to work. She did get better when we made homemade food for her, but she was getting to skinny and it was costing us more than we could afford the vet said to put her back on the dry food to regulate her weight better, and the allergies got bad again.

Rated 5 out of 5 stars
By Glen on Mar 29, 2026

My dog takes this pill by herself willingly

I used to place Apoquel pill at base of her tongue while holding her mouth open. Then I would rub her neck to cause swallow. But this chewable form is totally opposite

I used to place Apoquel pill at base of her tongue while holding her mouth open. Then I would rub her neck to cause swallow. But this chewable form is totally opposite. I offer to dog as a treat and she takes the pill with alacrity