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Advantage XD Large Cat Treatment, 4 count

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About This Item

Details

  • 2 months (1 dose) flea treatment and prevention for indoor and outdoor cats or kittens over 9 lbs., 8 weeks or older
  • Longer-lasting protection vs. other topical products; 2 months protection per dose, outlasting the typical flea life cycle
  • Fast-acting treatment starts killing fleas through contact within 30 minutes to 4 hours
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, containing a naturally derived ingredient Spinetoram - winner of a Green Chemistry award* *US EPA Presidential Green Chemistry Challenge. Designing Greener Chemicals Award. 2008.

Ingredient Information

Instructions

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Questions & Answers

7 Customer Questions

This is supposed to have an expiration date or manufacturers date. Neither of which I see on the box or anywhere tube or otherwise. Could you please explain why it doesn't as I am told it's supposed to.

What is difference between Advantage XD and II? I want one that is safe, but kills fleas, not just caused them to crawl to top.

Answer by Mary • Apr 09, 2026
The XD last for two months, versus the other II, last for one month.

Does this protect my cats from ticks also?

Answer by Chewy • Aug 19, 2023
This product has been proven to kill fleas. The formula starts working in as little as 30 minutes to 4 hours. It continues killing fleas for two months, which outlasts the typical six-week flea life cycle and prevents reinfestations.

When is it safe to pet my cat again?

Answer by Chewy • Oct 10, 2024
It is safe to pet your cat once the treatment has completely dried. It is also advised to not let cats groom themselves or other cats until the treatment has dried as well.
Reviews
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4.4
Rated 4.4 out of 5 stars
668 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

81% Positive

Effectiveness

81% Positive

Ingredients

74% Positive

Long-Term Benefits

79% Positive

287 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By HARRIETTE on Jan 22, 2026

IT WORKS!

I have a small colony of feral cats which I provide food & outside shelter for. I felt really bad for the adult male cat who scratches incessantly. They only allow

I have a small colony of feral cats which I provide food & outside shelter for. I felt really bad for the adult male cat who scratches incessantly. They only allow me to rub them during feeding time. I was able to put the Advantage XD on the back of the neck of the male the female adult car. And I have not seen on iota of scratching!! This stuff works!! I am so glad I tried it!

Rated 3 out of 5 stars
By Jennifer on Oct 21, 2025

Too much liquid

I always buy the one month Andvantage II, so when I saw this and it was for two months and was cheaper than buying two months of Advantage II I figured I'd get this

I always buy the one month Andvantage II, so when I saw this and it was for two months and was cheaper than buying two months of Advantage II I figured I'd get this. It works just fine for fleas, it's still Advantage after all, but the problem I have with it is it's twice as much liquid at one time. I thought it would be a stronger product, but it seems like it's the same amount of fluid as it would be if you put two tubes of the monthly product on at one time, for a small cat it's just too much. It ran down their sides and their backs while I'm trying to hold them still so it doesn't run completely off of them. I put it on three days ago and my cats are still wet looking and sticky everywhere the fluid went. If you have a large dog this would probably be fine, but I would not recommend for cats.

Rated 5 out of 5 stars
By Amy on Sep 26, 2024

Effective and long lasting

Easy to apply although it does leave my cat’s hair a bit oily for a few days. Treatment is effective and lasts as long as stated. My cat had bad flea infestation

Easy to apply although it does leave my cat’s hair a bit oily for a few days. Treatment is effective and lasts as long as stated. My cat had bad flea infestation and was constantly scratching and biting at himself earlier this spring. Since the medication, the flea are gone and he doesn’t scratch himself. This product is much more effective than “regular “ Advantage med. My cat is a large (15 lb) long hair indoor/outdoor cat.

Rated 5 out of 5 stars
By Brigitte on Feb 26, 2026

works great!

I can definitely tell a difference if I’m late giving it to him. It usually lasts just a little over two months but I try tostay on schedule. His coat looks so much

I can definitely tell a difference if I’m late giving it to him. It usually lasts just a little over two months but I try tostay on schedule. His coat looks so much better. He’s a munchkin cat. He has very short legs so it’s hard for him to scratch. This takes care of that.

Rated 5 out of 5 stars
By Elizabeth on Jul 20, 2025

No Fleas!!!

Sunshine is a big sweet baby that everyone loves including the fleas. He is normally covered in them. I have previously tried the flea collars and drop treatments

Sunshine is a big sweet baby that everyone loves including the fleas. He is normally covered in them. I have previously tried the flea collars and drop treatments to no avail. This worked so well that there was a noticeable lack of fleas on him almost overnight.

Rated 1 out of 5 stars
By Anita on Mar 10, 2025

Very bad for some cats ok on others

I treated 4 cats between 7-8 pm. The next morning 1 cat had lost fur & had an open wound in application spot. Not sure if it burned him but it caused an ulcer-type

I treated 4 cats between 7-8 pm. The next morning 1 cat had lost fur & had an open wound in application spot. Not sure if it burned him but it caused an ulcer-type wound. He will most likely require antibiotics at the vet. The wound is very bad. Washing it with antiseptic soap & applying antibiotic ointment.

Rated 3 out of 5 stars
By Geoff on Feb 9, 2026
Top 1000 Contributor

darn but no

Used on our 8 lb (miss you jenny :( )cat after the dogs brought home "friends' from the woods. Poor Jen, it did nothing to alleviate her discomfort and the dreaded

Used on our 8 lb (miss you jenny :( )cat after the dogs brought home "friends' from the woods. Poor Jen, it did nothing to alleviate her discomfort and the dreaded Bath was needed. Along with 100 load of hot wash laundry.

Rated 4 out of 5 stars
By Brett on Jul 24, 2025

Very wet

The product definitely works well for fleas, but there’s a lot more liquid to apply than the one month Advantage II It tends to run a bit, the added wetness was

The product definitely works well for fleas, but there’s a lot more liquid to apply than the one month Advantage II It tends to run a bit, the added wetness was more upsetting to my more sensitive babies and my two longer coated cats , Molly and Puca get mats in their fur at the application site, especially Puca who is a ragdoll It isn’t a bad product, but since my babies are indoor only except for their enclosed outdoor condo I have no worry about ticks so I think I’ll switch back to the Advantage II

Rated 4 out of 5 stars
By caitlin on Oct 7, 2024

flea meds

I can't say if this will have a reaction to my cats or how well it will work as I jut applied it last night. I will say that the directions definitely lack details

I can't say if this will have a reaction to my cats or how well it will work as I jut applied it last night. I will say that the directions definitely lack details. The "lid" was SO confusing! I, like others, thought you had to remove the cap!! Not the case but it's not listed anywhere on the directions! It also has no answer as to how long it takes to dry, if you need to apply the full tube and when you can safely pet your cat again!! I was very irritated with the paper insert. It needs to be fixed!

Rated 5 out of 5 stars
By Ingrid on Feb 19, 2025

Works great

A couple of hours after applying the product fleas started to surface. So it works great. Let's see if it lasts for two month. This is the first time using this

A couple of hours after applying the product fleas started to surface. So it works great. Let's see if it lasts for two month. This is the first time using this product. The last spot treatment from Adams was not strong enough. I mentioned that in my review, and was pleasantly surprised when I got a refund from Chewy. A big thank you to the Chewy team.